ENSMUSG00000035692


Mus musculus

Features
Gene ID: ENSMUSG00000035692
  
Biological name :Isg15
  
Synonyms : Isg15 / Q64339 / Ubiquitin-like protein ISG15
  
Possible biological names infered from orthology : ISG15 ubiquitin-like modifier / P05161
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 156199424
Gene end: 156200818
  
Corresponding Affymetrix probe sets: 10451287 (MoGene1.0st)   1431591_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082548
NCBI entrez gene - 100038882     See in Manteia.
MGI - MGI:1855694
RefSeq - NM_015783
RefSeq Peptide - NP_056598
swissprot - Q4FJR9
swissprot - Q64339
Ensembl - ENSMUSG00000035692
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isg15ENSDARG00000086374Danio rerio
 ISG15ENSG00000187608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ubc / P0CG50 / ubiquitin C / P0CG48*ENSMUSG0000000834823
Ubb / P0CG49 / ubiquitin BENSMUSG0000001950523
Gm8797 / UBB* / P0CG47* / ubiquitin B*ENSMUSG000001030346


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019941 modification-dependent protein catabolic process IDA
 biological_processGO:0030501 positive regulation of bone mineralization IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0032020 ISG15-protein conjugation IEA
 biological_processGO:0032649 regulation of interferon-gamma production ISO
 biological_processGO:0034340 response to type I interferon IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0051607 defense response to virus ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031386 protein tag IDA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Termination of translesion DNA synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Srftm1Nor/Srftm1Nor
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000275 Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*  / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / reaction
 ENSMUSG00000023953 Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*  / reaction
 ENSMUSG00000021774 P52482 / Ube2e1 / ubiquitin-conjugating enzyme E2E 1 / P51965*  / complex / reaction
 ENSMUSG00000021668 Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*  / reaction
 ENSMUSG00000026082 Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*  / reaction
 ENSMUSG00000038425 Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*  / reaction
 ENSMUSG00000093661 Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*  / reaction
 ENSMUSG00000032596 Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex
 ENSMUSG00000025278 Flnb / Q80X90 / Filamin-B / O75369*  / complex / reaction
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / reaction
 ENSMUSG00000061130 Ppm1b / P36993 / protein phosphatase 1B, magnesium dependent, beta isoform / O75688* / protein phosphatase, Mg2+/Mn2+ dependent 1B*  / complex / reaction
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction / complex
 ENSMUSG00000032216 Nedd4 / P46935 / neural precursor cell expressed, developmentally down-regulated 4 / P46934* / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase*  / complex / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / complex / reaction
 ENSMUSG00000026254 Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*  / reaction / complex
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000020905 Usp43 / Q8BUM9 / ubiquitin specific peptidase 43 / Q70EL4*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction / complex
 ENSMUSG00000059796 Eif4a1 / P60843 / Eukaryotic initiation factor 4A-I / P60842* / eukaryotic translation initiation factor 4A1*  / reaction






 

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