ENSMUSG00000027342


Mus musculus

Features
Gene ID: ENSMUSG00000027342
  
Biological name :Pcna
  
Synonyms : P17918 / Pcna / proliferating cell nuclear antigen
  
Possible biological names infered from orthology : P12004
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F2
Gene start: 132249162
Gene end: 132253314
  
Corresponding Affymetrix probe sets: 10461391 (MoGene1.0st)   10487930 (MoGene1.0st)   1417947_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028817
NCBI entrez gene - 18538     See in Manteia.
MGI - MGI:97503
RefSeq - NM_011045
RefSeq Peptide - NP_035175
swissprot - P17918
swissprot - Q542J9
Ensembl - ENSMUSG00000027342
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcnaENSDARG00000054155Danio rerio
 PCNAENSGALG00000029292Gallus gallus
 PCNAENSG00000132646Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcna-ps2 / PCNA* / P12004* / proliferating cell nuclear antigen*ENSMUSG0000006760899


Protein motifs (from Interpro)
Interpro ID Name
 IPR000730  Proliferating cell nuclear antigen, PCNA
 IPR022648  Proliferating cell nuclear antigen, PCNA, N-terminal
 IPR022649  Proliferating cell nuclear antigen, PCNA, C-terminal
 IPR022659  Proliferating cell nuclear antigen, PCNA, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006272 leading strand elongation IBA
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006287 base-excision repair, gap-filling IDA
 biological_processGO:0006298 mismatch repair IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0019985 translesion synthesis IBA
 biological_processGO:0031297 replication fork processing IGI
 biological_processGO:0032077 positive regulation of deoxyribonuclease activity ISO
 biological_processGO:0034644 cellular response to UV ISO
 biological_processGO:0045739 positive regulation of DNA repair ISO
 biological_processGO:0045740 positive regulation of DNA replication ISS
 biological_processGO:0071466 cellular response to xenobiotic stimulus IDA
 biological_processGO:1902990 mitotic telomere maintenance via semi-conservative replication IGI
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IPI
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005652 nuclear lamina IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005657 replication fork ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0043596 nuclear replication fork ISO
 cellular_componentGO:0043626 PCNA complex ISO
 cellular_componentGO:0070557 PCNA-p21 complex ISO
 molecular_functionGO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003684 damaged DNA binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030337 DNA polymerase processivity factor activity IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO
 molecular_functionGO:0032139 dinucleotide insertion or deletion binding ISO
 molecular_functionGO:0032405 MutLalpha complex binding ISO
 molecular_functionGO:0035035 histone acetyltransferase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0070182 DNA polymerase binding ISO


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak,Tg(Nes-cre/ERT2)4Kag/0
Genetic Background: involves: C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0004806 absent germ cells "absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Pcnatm1Jcbs/Pcnatm1Jcbs
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pcnatm1Jcbs/Pcnatm1Jcbs
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pcnatm1Jcbs/Pcnatm1Jcbs,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak,Tg(Nes-cre/ERT2)4Kag/0
Genetic Background: involves: C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
Show

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005262 Ufd1 / P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Q92890*  / complex / reaction
 ENSMUSG00000020390 Ube2b / P63147 / ubiquitin-conjugating enzyme E2B / P63146*  / complex / reaction
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / complex / reaction
 ENSMUSG00000019841 Rev3l / Q61493 / DNA polymerase zeta catalytic subunit / O60673* / REV3 like, DNA directed polymerase zeta catalytic subunit*  / reaction / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / reaction / complex
 ENSMUSG00000023953 Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*  / complex / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex / reaction
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSMUSG00000021668 Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / reaction / complex
 ENSMUSG00000026082 Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*  / reaction / complex
 ENSMUSG00000037474 Dtl / Q3TLR7 / Denticleless protein homolog / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / reaction / complex
 ENSMUSG00000039703 Nploc4 / P60670 / Nuclear protein localization / Q8TAT6* / NPL4 homolog, ubiquitin recognition factor*  / complex / reaction
 ENSMUSG00000031986 Sprtn / G3X912 / SprT-like domain-containing protein Spartan / Q9H040* / SprT-like N-terminal domain*  / complex / reaction
 ENSMUSG00000029003 Mad2l2 / Q9D752 / Mitotic spindle assembly checkpoint protein MAD2B / Q9UI95* / mitotic arrest deficient 2 like 2*  / reaction / complex
 ENSMUSG00000038425 Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*  / reaction / complex
 ENSMUSG00000028560 Usp1 / Q8BJQ2 / ubiquitin specific peptidase 1 / O94782*  / complex / reaction
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex / reaction
 ENSMUSG00000032596 Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*  / reaction
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction
 ENSMUSG00000079109 Pms2 / PMS1 homolog2, mismatch repair system component / P54278*  / reaction / complex
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction / complex
 ENSMUSG00000024151 Msh2 / P43247 / DNA mismatch repair protein Msh2 / P43246* / mutS homolog 2*  / complex / reaction
 ENSMUSG00000090112 Shprh / Q7TPQ3 / E3 ubiquitin-protein ligase SHPRH / Q149N8* / SNF2 histone linker PHD RING helicase*  / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000000275 Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*  / reaction / complex
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / reaction / complex
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / reaction / complex
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / reaction
 ENSMUSG00000031536 Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*  / reaction
 ENSMUSG00000030254 Rad18 / Q9QXK2 / RAD18 E3 ubiquitin protein ligase / Q9NS91*  / complex / reaction
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / complex / reaction
 ENSMUSG00000036390 P48316 / Gadd45a / Growth arrest and DNA damage-inducible protein GADD45 alpha / P24522* / growth arrest and DNA damage inducible alpha*  / reaction / complex
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000056394 Lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*  / complex / reaction
 ENSMUSG00000032498 Mlh1 / Q9JK91 / DNA mismatch repair protein Mlh1 / P40692* / mutL homolog 1*  / complex / reaction
 ENSMUSG00000020905 Usp43 / Q8BUM9 / ubiquitin specific peptidase 43 / Q70EL4*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000005370 Msh6 / P54276 / DNA mismatch repair protein Msh6 / P52701* / mutS homolog 6*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000032512 Wdr48 / Q8BH57 / WD repeat domain 48 / Q8TAF3*  / complex / reaction






 

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