ENSMUSG00000031986


Mus musculus

Features
Gene ID: ENSMUSG00000031986
  
Biological name :Sprtn
  
Synonyms : G3X912 / SprT-like domain-containing protein Spartan / Sprtn
  
Possible biological names infered from orthology : Q9H040 / SprT-like N-terminal domain
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E2
Gene start: 124897886
Gene end: 124906161
  
Corresponding Affymetrix probe sets: 10576524 (MoGene1.0st)   1436348_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034467
NCBI entrez gene - 244666     See in Manteia.
MGI - MGI:2685351
RefSeq - NM_001111141
RefSeq - XM_006531020
RefSeq Peptide - NP_001104611
swissprot - G3X912
Ensembl - ENSMUSG00000031986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sprtnENSDARG00000104709Danio rerio
 SPRTNENSGALG00000011065Gallus gallus
 SPRTNENSG00000010072Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006640  SprT-like
 IPR006642  Zinc finger, Rad18-type putative


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0019985 translesion synthesis IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IBA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Translesion Synthesis by POLH


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: Sprtntm1Yjm/Sprtntm1.2Yjm
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

Allelic Composition: Sprtntm1Yjm/Sprtntm1.2Yjm
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0009303 decreased renal fat pad weight 
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Sprtntm1Yjm/Sprtntm1.2Yjm
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Sprtntm1Yjm/Sprtntm1.2Yjm
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Sprtntm1Yjm/Sprtntm1.2Yjm
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0012113 decreased inner cell mass proliferation 
Show

Allelic Composition: Sprtntm1Yjm/Sprtntm1.2Yjm
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000005262 Ufd1 / P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Q92890*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000023953 Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*  / reaction / complex
 ENSMUSG00000039703 Nploc4 / P60670 / Nuclear protein localization / Q8TAT6* / NPL4 homolog, ubiquitin recognition factor*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / reaction / complex






 

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