ENSMUSG00000023953


Mus musculus

Features
Gene ID: ENSMUSG00000023953
  
Biological name :Polh
  
Synonyms : DNA polymerase eta / Polh / Q9JJN0
  
Possible biological names infered from orthology : Q9Y253
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46172004
Gene end: 46202625
  
Corresponding Affymetrix probe sets: 10451225 (MoGene1.0st)   1420988_at (Mouse Genome 430 2.0 Array)   1447837_x_at (Mouse Genome 430 2.0 Array)   1450075_at (Mouse Genome 430 2.0 Array)   1459539_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024749
NCBI entrez gene - 80905     See in Manteia.
MGI - MGI:1891457
RefSeq - NM_030715
RefSeq - XM_006525176
RefSeq Peptide - NP_109640
swissprot - Q9JJN0
Ensembl - ENSMUSG00000023953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polhENSDARG00000070231Danio rerio
 POLHENSGALG00000010317Gallus gallus
 POLHENSG00000170734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*ENSMUSG0000003842521
Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*ENSMUSG0000002166819
Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*ENSMUSG0000002608218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR017061  DNA polymerase eta/kappa/iota/IV
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR036775  DNA polymerase, Y-family, little finger domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000731 DNA synthesis involved in DNA repair IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006290 pyrimidine dimer repair IDA
 biological_processGO:0006301 postreplication repair IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010225 response to UV-C IEA
 biological_processGO:0071494 cellular response to UV-C IMP
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion Synthesis by POLH
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000015 abnormal ear pigmentation "anomaly in the coloration of the ear" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

 MP:0001202 skin photosensitivity "abnormally heightened reactivity of the skin to sunlight " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpbar1tm1Ktan/Gpbar1+
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0001203 skin irradiation sensitivity "increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
Show

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Polhtm2Fmh/Polh+
Genetic Background: B6.129-Polhtm2Fmh

Allelic Composition: Polhtm2Fmh/Polhtm2Fmh,Polid/Poli+
Genetic Background: B6.129-Polhtm2Fmh Polid

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Polhtm1Crey/Polhtm1Crey,Polid/Polid
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Polhtm1Fmh/Polhtm1Fmh
Genetic Background: involves: C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

 MP:0004501 increased incidence of UV-induced tumors "higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

Allelic Composition: Polhtm2Fmh/Polhtm2Fmh
Genetic Background: B6.129-Polhtm2Fmh

Allelic Composition: Polhtm2Fmh/Polh+
Genetic Background: B6.129-Polhtm2Fmh

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

Allelic Composition: Polhtm1.1Rak/Polh+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction
 ENSMUSG00000039703 Nploc4 / P60670 / Nuclear protein localization / Q8TAT6* / NPL4 homolog, ubiquitin recognition factor*  / complex / reaction
 ENSMUSG00000000275 Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*  / complex / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000005262 Ufd1 / P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Q92890*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction / complex
 ENSMUSG00000032596 Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*  / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000031986 Sprtn / G3X912 / SprT-like domain-containing protein Spartan / Q9H040* / SprT-like N-terminal domain*  / reaction / complex
 ENSMUSG00000029397 Rchy1 / Q9CR50 / ring finger and CHY zinc finger domain containing 1 / Q96PM5*  / reaction / complex






 

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