ENSMUSG00000028884


Mus musculus

Features
Gene ID: ENSMUSG00000028884
  
Biological name :Rpa2
  
Synonyms : replication protein A2 / Rpa2
  
Possible biological names infered from orthology : P15927
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.3
Gene start: 132768332
Gene end: 132778752
  
Corresponding Affymetrix probe sets: 10508759 (MoGene1.0st)   1416433_at (Mouse Genome 430 2.0 Array)   1454011_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099621
Ensembl peptide - ENSMUSP00000123780
NCBI entrez gene - 19891     See in Manteia.
MGI - MGI:1339939
RefSeq - NM_011284
RefSeq Peptide - NP_035414
swissprot - F6V8R7
swissprot - Q3TE40
Ensembl - ENSMUSG00000028884
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpa2ENSDARG00000037188Danio rerio
 RPA2ENSGALG00000000734Gallus gallus
 RPA2ENSG00000117748Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012340  Nucleic acid-binding, OB-fold
 IPR014646  Replication factor A protein 2
 IPR014892  Replication protein A, C-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IEA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IEA
 biological_processGO:0034502 protein localization to chromosome IEA
 biological_processGO:2000001 regulation of DNA damage checkpoint IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005662 DNA replication factor A complex IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction
 ENSMUSG00000005262 Ufd1 / P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Q92890*  / complex / reaction
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000020390 Ube2b / P63147 / ubiquitin-conjugating enzyme E2B / P63146*  / complex / reaction
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / reaction / complex
 ENSMUSG00000020413 Hus1 / Q8BQY8 / Checkpoint protein HUS1 / O60921* / HUS1 checkpoint clamp component*  / complex / reaction
 ENSMUSG00000019841 Rev3l / Q61493 / DNA polymerase zeta catalytic subunit / O60673* / REV3 like, DNA directed polymerase zeta catalytic subunit*  / reaction / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex
 ENSMUSG00000023953 Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*  / reaction / complex
 ENSMUSG00000024824 Rad9a / Q9Z0F6 / Cell cycle checkpoint control protein RAD9A / Q99638* / RAD9 checkpoint clamp component A*  / complex / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex / reaction
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / complex / reaction
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSMUSG00000021668 Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000022248 Rad1 / Q9QWZ1 / Cell cycle checkpoint protein RAD1 / O60671* / RAD1 checkpoint DNA exonuclease*  / complex / reaction
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / reaction / complex
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSMUSG00000026429 Ube2t / Q9CQ37 / ubiquitin-conjugating enzyme E2T / Q9NPD8*  / complex / reaction
 ENSMUSG00000026082 Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*  / reaction / complex
 ENSMUSG00000037474 Dtl / Q3TLR7 / Denticleless protein homolog / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / reaction / complex
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex / reaction
 ENSMUSG00000039703 Nploc4 / P60670 / Nuclear protein localization / Q8TAT6* / NPL4 homolog, ubiquitin recognition factor*  / complex / reaction
 ENSMUSG00000031986 Sprtn / G3X912 / SprT-like domain-containing protein Spartan / Q9H040* / SprT-like N-terminal domain*  / complex / reaction
 ENSMUSG00000029003 Mad2l2 / Q9D752 / Mitotic spindle assembly checkpoint protein MAD2B / Q9UI95* / mitotic arrest deficient 2 like 2*  / reaction / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSMUSG00000038425 Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*  / complex / reaction
 ENSMUSG00000030697 Ppp4c / P97470 / protein phosphatase 4, catalytic subunit / P60510*  / reaction
 ENSMUSG00000028560 Usp1 / Q8BJQ2 / ubiquitin specific peptidase 1 / O94782*  / complex / reaction
 ENSMUSG00000039187 Fanci / Q8K368 / Fanconi anemia group I protein homolog / Q9NVI1* / Fanconi anemia complementation group I*  / reaction / complex
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex / reaction
 ENSMUSG00000034023 Fancd2 / Q80V62 / Fanconi anemia group D2 protein homolog / Q9BXW9* / Fanconi anemia complementation group D2*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex
 ENSMUSG00000032512 Wdr48 / Q8BH57 / WD repeat domain 48 / Q8TAF3*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000030254 Rad18 / Q9QXK2 / RAD18 E3 ubiquitin protein ligase / Q9NS91*  / reaction / complex
 ENSMUSG00000038569 Rad9b / Q6WBX7 / RAD9 checkpoint clamp component B / Q6WBX8*  / reaction / complex
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / complex / reaction
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000052144 Ppp4r2 / protein phosphatase 4 regulatory subunit 2 / Q9NY27*  / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction / complex
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / complex / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / complex / reaction
 ENSMUSG00000056394 Lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction / complex
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex / reaction
 ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*  / complex / reaction
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / reaction / complex
 ENSMUSG00000031536 Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*  / reaction
 ENSMUSG00000026669 Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*  / reaction / complex
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / complex / reaction
 ENSMUSG00000000275 Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*  / reaction / complex
 ENSMUSG00000022545 Ercc4 / Q9QZD4 / DNA repair endonuclease XPF / Q92889* / ERCC excision repair 4, endonuclease catalytic subunit*  / complex / reaction
 ENSMUSG00000003549 Ercc1 / P07903 / DNA excision repair protein ERCC-1 / P07992* / ERCC excision repair 1, endonuclease non-catalytic subunit*  / reaction / complex
 ENSMUSG00000029283 Cdc7 / Q9Z0H0 / Cell division cycle 7-related protein kinase / O00311* / cell division cycle 7*  / complex / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction / complex
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / reaction / complex
 ENSMUSG00000032596 Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*  / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction / complex
 ENSMUSG00000000028 Cdc45 / Q9Z1X9 / Cell division control / O75419* / cell division cycle 45*  / complex / reaction
 ENSMUSG00000020905 Usp43 / Q8BUM9 / ubiquitin specific peptidase 43 / Q70EL4*  / reaction / complex
 ENSMUSG00000002297 A / Dbf4 / Q9QZ41 / Q9UBU7* / DBF4 zinc finger*  / reaction / complex
 ENSMUSG00000031583 Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*  / complex / reaction
 ENSMUSG00000026048 Ercc5 / ERCC excision repair 5, endonuclease / P28715*  / complex / reaction
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / complex / reaction
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / reaction / complex






 

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