Manteia

ENSMUSG00000041238

Mus musculus

Features

Gene ID:	ENSMUSG00000041238

Biological name :	Rbbp8

Synonyms :	Q80YR6 / Rbbp8 / retinoblastoma binding protein 8, endonuclease

Possible biological names infered from orthology :	Q99708 / RB binding protein 8, endonuclease

Species:	Mus musculus

Chr. number:	18
Strand:	1
Band:	A1
Gene start:	11633276
Gene end:	11743207

Corresponding Affymetrix probe sets:	10453867 (MoGene1.0st) 1427061_at (Mouse Genome 430 2.0 Array) 1427062_at (Mouse Genome 430 2.0 Array) 1446097_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000046255 Ensembl peptide - ENSMUSP00000111527 NCBI entrez gene - 225182 See in Manteia. MGI - MGI:2442995 RefSeq - XM_006525812 RefSeq - NM_001081223 RefSeq - NM_001252495 RefSeq Peptide - NP_001239424 RefSeq Peptide - NP_001074692 swissprot - Q80YR6 Ensembl - ENSMUSG00000041238

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rbbp8	ENSDARG00000043480	Danio rerio
RBBP8	ENSGALG00000014982	Gallus gallus
RBBP8	ENSG00000101773	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rbbp8nl / RBBP8 N-terminal like / Q8NC74*	ENSMUSG00000038980	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR013882	DNA endonuclease Ctp1, C-terminal
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR019518	DNA endonuclease Ctp1, N-terminal
IPR033316	DNA endonuclease RBBP8-like
IPR033594	DNA endonuclease RBBP8

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000082	G1/S transition of mitotic cell cycle	IMP
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0000724	double-strand break repair via homologous recombination	ISS
biological_process	GO:0001835	blastocyst hatching	IMP
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006289	nucleotide-excision repair	ISO
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	ISO
biological_process	GO:0031572	G2 DNA damage checkpoint	ISS
biological_process	GO:0032355	response to estradiol	IEA
biological_process	GO:0051301	cell division	IEA
biological_process	GO:0051321	meiotic cell cycle	IEA
biological_process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA
biological_process	GO:1903507	negative regulation of nucleic acid-templated transcription	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005694	chromosome	IEA
cellular_component	GO:0017053	transcriptional repressor complex	ISO
cellular_component	GO:0043231	intracellular membrane-bounded organelle	ISO
molecular_function	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	ISO
molecular_function	GO:0001103	RNA polymerase II repressing transcription factor binding	ISO
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003684	damaged DNA binding	ISO
molecular_function	GO:0004518	nuclease activity	IEA
molecular_function	GO:0004519	endonuclease activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0042802	identical protein binding	ISO

Pathways (from Reactome)

Pathway description

HDR through Single Strand Annealing (SSA)

HDR through MMEJ (alt-NHEJ)

HDR through Homologous Recombination (HRR)

Resolution of D-loop Structures through Holliday Junction Intermediates

Homologous DNA Pairing and Strand Exchange

Processing of DNA double-strand break ends

Presynaptic phase of homologous DNA pairing and strand exchange

Regulation of TP53 Activity through Phosphorylation

G2/M DNA damage checkpoint

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001694	failure to form egg cylinders	"inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]	Show Allelic Composition: Kit^d18/Kit⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Kit^d18/Kit⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^d18/Kit⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Kit^d18/Kit⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003694	failure to hatch from the zona pellucida	"the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^d18/Kit⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011094	complete embryonic lethality before implantation	"death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]	Show Allelic Composition: Kit^d18/Kit⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Kit^d18/Kit⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000751	Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*	/ complex / reaction
ENSMUSG00000020380	Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*	/ complex / reaction
ENSMUSG00000012483	Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*	/ complex / reaction
ENSMUSG00000025358	Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*	/ reaction / complex
ENSMUSG00000024742	Fen1 / flap structure-specific endonuclease 1 / P39748*	/ complex / reaction
ENSMUSG00000028224	Nbn / Q9R207 / Nibrin / O60934*	/ reaction / complex
ENSMUSG00000032409	Atr / ATR serine/threonine kinase / Q13535*	/ complex / reaction
ENSMUSG00000034748	Sirt6 / P59941 / sirtuin 6 / Q8N6T7*	/ reaction
ENSMUSG00000031928	Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*	/ complex / reaction
ENSMUSG00000026496	Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*	/ reaction / complex
ENSMUSG00000041238	Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*	/ complex
ENSMUSG00000002814	Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*	/ reaction / complex
ENSMUSG00000044702	Palb2 / Q3U0P1 / Partner and localizer of BRCA2 / Q86YC2*	/ complex
ENSMUSG00000034218	Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*	/ complex / reaction
ENSMUSG00000036875	Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*	/ complex / reaction
ENSMUSG00000024926	Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*	/ complex / reaction
ENSMUSG00000017146	Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*	/ reaction / complex
ENSMUSG00000039748	Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*	/ reaction / complex
ENSMUSG00000034206	Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*	/ reaction / complex
ENSMUSG00000030528	Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*	/ complex / reaction
ENSMUSG00000026196	Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*	/ complex / reaction
ENSMUSG00000035367	Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*	/ reaction / complex
ENSMUSG00000037991	Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*	/ complex / reaction
ENSMUSG00000034329	Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*	/ complex / reaction
ENSMUSG00000030346	Rad51ap1 / RAD51-associated protein 1 isoform 2 / Q96B01* / RAD51 associated protein 1*	/ complex
ENSMUSG00000031583	Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*	/ complex / reaction
ENSMUSG00000028884	Rpa2 / replication protein A2 / P15927*	/ complex / reaction
ENSMUSG00000025646	Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*	/ reaction / complex
ENSMUSG00000051768	Xrcc1 / Q60596 / X-ray repair complementing defective repair in Chinese hamster cells 1 / P18887* / X-ray repair cross complementing 1*	/ reaction / complex
ENSMUSG00000041147	Brca2 / P97929 / Breast cancer type 2 susceptibility protein homolog / P51587* / BRCA2, DNA repair associated*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr