ENSMUSG00000030528


Mus musculus

Features
Gene ID: ENSMUSG00000030528
  
Biological name :Blm
  
Synonyms : Blm / Bloom syndrome protein homolog / O88700
  
Possible biological names infered from orthology : Bloom syndrome RecQ like helicase / P54132
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 80454733
Gene end: 80535119
  
Corresponding Affymetrix probe sets: 10564978 (MoGene1.0st)   1448953_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080062
Ensembl peptide - ENSMUSP00000146098
Ensembl peptide - ENSMUSP00000146062
Ensembl peptide - ENSMUSP00000145573
Ensembl peptide - ENSMUSP00000127995
NCBI entrez gene - 12144     See in Manteia.
MGI - MGI:1328362
RefSeq - XM_017321956
RefSeq - NM_001042527
RefSeq - NM_007550
RefSeq Peptide - NP_001035992
RefSeq Peptide - NP_031576
swissprot - E9PZ97
swissprot - A0A0U1RPS3
swissprot - A0A0U1RNI0
swissprot - A0A0U1RPP0
swissprot - O88700
Ensembl - ENSMUSG00000030528
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 blmENSDARG00000077089Danio rerio
 BLMENSGALG00000008256Gallus gallus
 BLMENSG00000197299Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*ENSMUSG0000003158319
Q8VID5 / Recql5 / ATP-dependent DNA helicase Q5 / O94762* / RecQ like helicase 5*ENSMUSG0000002075217
Recql / Q9Z129 / RecQ protein-like / P46063* / RecQ like helicase*ENSMUSG0000003024316
Recql4 / RecQ like helicase 4ENSMUSG0000003376214


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002121  HRDC domain
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR004589  DNA helicase, ATP-dependent, RecQ type
 IPR010997  HRDC-like superfamily
 IPR011545  DEAD/DEAH box helicase domain
 IPR012532  BDHCT
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR018982  RQC domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032284  ATP-dependent DNA helicase RecQ, zinc-binding domain
 IPR032437  Bloom syndrome protein, N-terminal domain
 IPR032439  Bloom syndrome protein, BDHCT-box associated domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0000723 telomere maintenance IGI
 biological_processGO:0000729 DNA double-strand break processing IEA
 biological_processGO:0000733 DNA strand renaturation IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0035690 cellular response to drug IGI
 biological_processGO:0044237 cellular metabolic process IEA
 biological_processGO:0044806 G-quadruplex DNA unwinding IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045910 negative regulation of DNA recombination IEA
 biological_processGO:0045950 negative regulation of mitotic recombination IMP
 biological_processGO:0046632 alpha-beta T cell differentiation IMP
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IMP
 biological_processGO:0051098 regulation of binding IDA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0051782 negative regulation of cell division IEA
 biological_processGO:0061820 telomeric D-loop disassembly IEA
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IMP
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0072711 cellular response to hydroxyurea IEA
 biological_processGO:0072757 cellular response to camptothecin IEA
 biological_processGO:0090329 regulation of DNA-dependent DNA replication IEA
 biological_processGO:1905168 positive regulation of double-strand break repair via homologous recombination IGI
 biological_processGO:1990414 replication-born double-strand break repair via sister chromatid exchange IMP
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000800 lateral element IEA
 cellular_componentGO:0001673 male germ cell nucleus IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0045120 pronucleus IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0000403 Y-form DNA binding IEA
 molecular_functionGO:0000405 bubble DNA binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0009378 four-way junction helicase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0036310 annealing helicase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051880 G-quadruplex DNA binding IEA
 molecular_functionGO:0061749 forked DNA-dependent helicase activity IEA
 molecular_functionGO:0061821 telomeric D-loop binding IEA
 molecular_functionGO:1905773 8-hydroxy-2"-deoxyguanosine DNA binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Becn1tm1Htz/Becn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Becn1tm1Htz/Becn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001599 abnormal blood volume "anomalous amount of space occupied by the blood in the vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Becn1tm1Htz/Becn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Becn1tm1Htz/Becn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Ift88tm1Rpw/Ift88tm1Rpw
Genetic Background: involves: 129/Sv

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
Show

Allelic Composition: Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ift88tm1Rpw/Ift88tm1Rpw
Genetic Background: involves: 129/Sv

Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Blmtm1Ches/Blmtm1Ches
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction / complex
 ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*  / complex
 ENSMUSG00000041974 Spidr / Q8BGX7 / DNA repair-scaffolding protein / Q14159* / scaffolding protein involved in DNA repair*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / reaction / complex
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / reaction / complex
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction






 

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