ENSMUSG00000041974


Mus musculus

Features
Gene ID: ENSMUSG00000041974
  
Biological name :Spidr
  
Synonyms : DNA repair-scaffolding protein / Q8BGX7 / Spidr
  
Possible biological names infered from orthology : Q14159 / scaffolding protein involved in DNA repair
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A2
Gene start: 15889224
Gene end: 16146851
  
Corresponding Affymetrix probe sets: 10437970 (MoGene1.0st)   1451171_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038820
NCBI entrez gene - 224008     See in Manteia.
MGI - MGI:1924834
RefSeq - XM_017316948
RefSeq - NM_146068
RefSeq - XM_017316946
RefSeq - XM_017316947
RefSeq Peptide - NP_666180
swissprot - Q8BGX7
Ensembl - ENSMUSG00000041974
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000015226Gallus gallus
 SPIDRENSG00000164808Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028026  Domain of unknown function DUF4502
 IPR028032  Domain of unknown function DUF4503


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0070202 regulation of establishment of protein localization to chromosome IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0072711 cellular response to hydroxyurea IEA
 biological_processGO:0072757 cellular response to camptothecin IEA
 biological_processGO:2000781 positive regulation of double-strand break repair IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / reaction / complex
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / complex / reaction
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / complex / reaction
 ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*  / reaction / complex






 

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