Manteia

ENSMUSG00000002814

Mus musculus

Features

Gene ID:	ENSMUSG00000002814

Biological name :	Top3a

Synonyms :	O70157 / Top3a / topoisomerase (DNA) III alpha

Possible biological names infered from orthology :	DNA topoisomerase III alpha / Q13472

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	B2
Gene start:	60740058
Gene end:	60777365

Corresponding Affymetrix probe sets:	10386582 (MoGene1.0st) 1418597_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000099729 Ensembl peptide - ENSMUSP00000113653 Ensembl peptide - ENSMUSP00000115727 Ensembl peptide - ENSMUSP00000002891 Ensembl peptide - ENSMUSP00000113057 NCBI entrez gene - 21975 See in Manteia. MGI - MGI:1197527 RefSeq - XM_017314499 RefSeq - NM_009410 RefSeq Peptide - NP_033436 swissprot - O70157 swissprot - Q3V3P1 swissprot - Q5NCT0 swissprot - Q5NCT1 swissprot - Q5NCT2 swissprot - B0QZI1 Ensembl - ENSMUSG00000002814

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
top3a	ENSDARG00000052827	Danio rerio
TOP3A	ENSGALG00000005028	Gallus gallus
TOP3A	ENSG00000177302	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Top3b / Q9Z321 / topoisomerase (DNA) III beta / O95985* / DNA topoisomerase III beta*	ENSMUSG00000022779	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR000380	DNA topoisomerase, type IA
IPR003601	DNA topoisomerase, type IA, domain 2
IPR003602	DNA topoisomerase, type IA, DNA-binding domain
IPR006171	TOPRIM domain
IPR010666	Zinc finger, GRF-type
IPR013497	DNA topoisomerase, type IA, central
IPR013498	DNA topoisomerase, type IA, zn finger
IPR013825	DNA topoisomerase, type IA, central region, subdomain 2
IPR023405	DNA topoisomerase, type IA, core domain
IPR023406	DNA topoisomerase, type IA, active site
IPR034144	DNA topoisomerase 3-like, TOPRIM domain
IPR036875	Zinc finger, CCHC-type superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006265	DNA topological change	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005694	chromosome	IEA
cellular_component	GO:0016605	PML body	IEA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003916	DNA topoisomerase activity	IEA
molecular_function	GO:0003917	DNA topoisomerase type I activity	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016853	isomerase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

HDR through Single Strand Annealing (SSA)

HDR through Homologous Recombination (HRR)

Resolution of D-loop Structures through Holliday Junction Intermediates

Homologous DNA Pairing and Strand Exchange

Processing of DNA double-strand break ends

Presynaptic phase of homologous DNA pairing and strand exchange

Regulation of TP53 Activity through Phosphorylation

G2/M DNA damage checkpoint

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0004966	abnormal inner cell mass proliferation	"any anomaly in the ability of the inner cell mass population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000751	Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*	/ complex / reaction
ENSMUSG00000034329	Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*	/ reaction / complex
ENSMUSG00000032409	Atr / ATR serine/threonine kinase / Q13535*	/ reaction / complex
ENSMUSG00000025646	Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*	/ complex / reaction
ENSMUSG00000031928	Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*	/ complex / reaction
ENSMUSG00000024926	Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*	/ complex / reaction
ENSMUSG00000020380	Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*	/ complex / reaction
ENSMUSG00000028224	Nbn / Q9R207 / Nibrin / O60934*	/ complex / reaction
ENSMUSG00000036875	Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*	/ complex
ENSMUSG00000034218	Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*	/ complex / reaction
ENSMUSG00000017146	Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*	/ reaction / complex
ENSMUSG00000012483	Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*	/ complex / reaction
ENSMUSG00000026196	Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*	/ complex / reaction
ENSMUSG00000035367	Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*	/ complex
ENSMUSG00000041974	Spidr / Q8BGX7 / DNA repair-scaffolding protein / Q14159* / scaffolding protein involved in DNA repair*	/ reaction / complex
ENSMUSG00000037991	Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*	/ complex
ENSMUSG00000041238	Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*	/ complex / reaction
ENSMUSG00000030528	Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*	/ complex
ENSMUSG00000028884	Rpa2 / replication protein A2 / P15927*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr