ENSDARG00000052827


Danio rerio

Features
Gene ID: ENSDARG00000052827
  
Biological name :top3a
  
Synonyms : DNA topoisomerase III alpha / top3a
  
Possible biological names infered from orthology : O70157 / Q13472 / topoisomerase (DNA) III alpha
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 40235288
Gene end: 40254634
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000127896
NCBI entrez gene - 560212     See in Manteia.
RefSeq - XM_683603
swissprot - X1WCF3
ZFIN ID - ZDB-GENE-071212-2
Ensembl - ENSDARG00000052827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TOP3AENSGALG00000005028Gallus gallus
 TOP3AENSG00000177302Homo sapiens
 Top3aENSMUSG00000002814Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
top3b / DNA topoisomerase III beta / O95985* / Q9Z321* / topoisomerase (DNA) III beta*ENSDARG0000002758628


Protein motifs (from Interpro)
Interpro ID Name
 IPR003601  DNA topoisomerase, type IA, domain 2
 IPR003602  DNA topoisomerase, type IA, DNA-binding domain
 IPR006171  TOPRIM domain
 IPR010666  Zinc finger, GRF-type
 IPR013497  DNA topoisomerase, type IA, central
 IPR013498  DNA topoisomerase, type IA, zn finger
 IPR013825  DNA topoisomerase, type IA, central region, subdomain 2
 IPR023405  DNA topoisomerase, type IA, core domain
 IPR023406  DNA topoisomerase, type IA, active site
 IPR034144  DNA topoisomerase 3-like, TOPRIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006265 DNA topological change IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001078 thymus thymus decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
Show

 ZFA:0009046 T cell T cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSDARG00000063076 atrip / ATR interacting protein / Q8BMG1* / Q8WXE1*  / reaction / complex
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / complex
 ENSDARG00000074410 brip1 / BRCA1 interacting protein C-terminal helicase 1 / Q5SXJ3* / Q9BX63* / Fanconi anemia group J protein homolog *  / reaction / complex
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / reaction / complex
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex
 ENSDARG00000103137 rmi2 / RecQ mediated genome instability 2 / Q3UPE3* / Q96E14* / RecQ-mediated genome instability protein 2 *  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr