ENSG00000177302


Homo sapiens

Features
Gene ID: ENSG00000177302
  
Biological name :TOP3A
  
Synonyms : DNA topoisomerase III alpha / Q13472 / TOP3A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 18271428
Gene end: 18315007
  
Corresponding Affymetrix probe sets: 204946_s_at (Human Genome U133 Plus 2.0 Array)   214299_at (Human Genome U133 Plus 2.0 Array)   214300_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466641
Ensembl peptide - ENSP00000465864
Ensembl peptide - ENSP00000466099
Ensembl peptide - ENSP00000321636
Ensembl peptide - ENSP00000442336
Ensembl peptide - ENSP00000462136
Ensembl peptide - ENSP00000462378
Ensembl peptide - ENSP00000462790
Ensembl peptide - ENSP00000464338
Ensembl peptide - ENSP00000464493
Ensembl peptide - ENSP00000465014
NCBI entrez gene - 7156     See in Manteia.
OMIM - 601243
RefSeq - XM_011524001
RefSeq - NM_001320759
RefSeq - NM_004618
RefSeq Peptide - NP_001307688
RefSeq Peptide - NP_004609
swissprot - K7EL07
swissprot - K7ELI7
swissprot - K7EMT6
swissprot - Q13472
swissprot - J3KRR9
swissprot - J3KS96
swissprot - J3QS25
swissprot - J3QR18
swissprot - K7EJ41
Ensembl - ENSG00000177302
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top3aENSDARG00000052827Danio rerio
 TOP3AENSGALG00000005028Gallus gallus
 Top3aENSMUSG00000002814Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP3B / O95985 / DNA topoisomerase III betaENSG0000010003829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000380  DNA topoisomerase, type IA
 IPR001878  Zinc finger, CCHC-type
 IPR003601  DNA topoisomerase, type IA, domain 2
 IPR003602  DNA topoisomerase, type IA, DNA-binding domain
 IPR006171  TOPRIM domain
 IPR010666  Zinc finger, GRF-type
 IPR013497  DNA topoisomerase, type IA, central
 IPR013498  DNA topoisomerase, type IA, zn finger
 IPR013825  DNA topoisomerase, type IA, central region, subdomain 2
 IPR023405  DNA topoisomerase, type IA, core domain
 IPR023406  DNA topoisomerase, type IA, active site
 IPR034144  DNA topoisomerase 3-like, TOPRIM domain
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000731 DNA synthesis involved in DNA repair TAS
 biological_processGO:0000732 strand displacement TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006265 DNA topological change IDA
 biological_processGO:0051321 meiotic cell cycle TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016605 PML body IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136492 BRIP1 / Q9BX63 / BRCA1 interacting protein C-terminal helicase 1  / complex / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000138376 BARD1 / Q99728 / BRCA1 associated RING domain 1  / reaction / complex
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / complex / reaction
 ENSG00000126215 XRCC3 / O43542 / X-ray repair cross complementing 3  / reaction
 ENSG00000164053 ATRIP / Q8WXE1 / ATR interacting protein  / reaction / complex
 ENSG00000164808 SPIDR / Q14159 / scaffolding protein involved in DNA repair  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000197299 BLM / P54132 / Bloom syndrome RecQ like helicase  / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000178966 RMI1 / Q9H9A7 / RecQ mediated genome instability 1  / complex
 ENSG00000108384 O43502 / RAD51C / RAD51 paralog C  / reaction
 ENSG00000175643 RMI2 / Q96E14 / RecQ mediated genome instability 2  / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction / complex
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / complex / reaction
 ENSG00000138346 DNA2 / P51530 / DNA replication helicase/nuclease 2  / complex
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / reaction / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction / complex






 

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