ENSG00000175643


Homo sapiens

Features
Gene ID: ENSG00000175643
  
Biological name :RMI2
  
Synonyms : Q96E14 / RecQ mediated genome instability 2 / RMI2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.13
Gene start: 11249619
Gene end: 11351762
  
Corresponding Affymetrix probe sets: 226456_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459601
Ensembl peptide - ENSP00000461206
Ensembl peptide - ENSP00000310356
NCBI entrez gene - 116028     See in Manteia.
OMIM - 612426
RefSeq - NM_152308
RefSeq Peptide - NP_689521
swissprot - I3L2E0
swissprot - Q96E14
Ensembl - ENSG00000175643
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rmi2ENSDARG00000103137Danio rerio
 RMI2ENSGALG00000007155Gallus gallus
 Rmi2ENSMUSG00000037991Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR032245  RecQ-mediated genome instability protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000731 DNA synthesis involved in DNA repair TAS
 biological_processGO:0000732 strand displacement TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0033045 regulation of sister chromatid segregation IMP
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136492 BRIP1 / Q9BX63 / BRCA1 interacting protein C-terminal helicase 1  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000138376 BARD1 / Q99728 / BRCA1 associated RING domain 1  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000164053 ATRIP / Q8WXE1 / ATR interacting protein  / complex / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000126215 XRCC3 / O43542 / X-ray repair cross complementing 3  / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction / complex
 ENSG00000108384 O43502 / RAD51C / RAD51 paralog C  / reaction
 ENSG00000164808 SPIDR / Q14159 / scaffolding protein involved in DNA repair  / reaction / complex
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000178966 RMI1 / Q9H9A7 / RecQ mediated genome instability 1  / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000177302 TOP3A / Q13472 / DNA topoisomerase III alpha  / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / complex / reaction
 ENSG00000138346 DNA2 / P51530 / DNA replication helicase/nuclease 2  / complex
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / complex / reaction
 ENSG00000197299 BLM / P54132 / Bloom syndrome RecQ like helicase  / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction / complex






 

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