Manteia

ENSG00000172977

Homo sapiens

Features

Gene ID:	ENSG00000172977

Biological name :	KAT5

Synonyms :	KAT5 / lysine acetyltransferase 5 / Q92993

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	11
Strand:	1
Band:	q13.1
Gene start:	65711996
Gene end:	65719604

Corresponding Affymetrix probe sets:	206689_x_at (Human Genome U133 Plus 2.0 Array) 209192_x_at (Human Genome U133 Plus 2.0 Array) 214258_x_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000366245 Ensembl peptide - ENSP00000436247 Ensembl peptide - ENSP00000436012 Ensembl peptide - ENSP00000436000 Ensembl peptide - ENSP00000435939 Ensembl peptide - ENSP00000435766 Ensembl peptide - ENSP00000434993 Ensembl peptide - ENSP00000434765 Ensembl peptide - ENSP00000431819 Ensembl peptide - ENSP00000340330 Ensembl peptide - ENSP00000344955 NCBI entrez gene - 10524 See in Manteia. OMIM - 601409 RefSeq - XM_006718421 RefSeq - NM_001206833 RefSeq - NM_006388 RefSeq - NM_182709 RefSeq - NM_182710 RefSeq Peptide - NP_874368 RefSeq Peptide - NP_874369 RefSeq Peptide - NP_001193762 RefSeq Peptide - NP_006379 swissprot - Q92993 swissprot - E9PRS1 swissprot - E9PRL6 swissprot - E9PMG8 swissprot - E9PJI1 swissprot - A0A024R597 swissprot - A0A024R5E8 swissprot - E9PRM3 swissprot - H0YEG3 swissprot - H0YEP0 Ensembl - ENSG00000172977

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kat5a	ENSDARG00000004587	Danio rerio
kat5b	ENSDARG00000045951	Danio rerio
Kat5	ENSMUSG00000024926	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
KAT6B / Q8WYB5 / lysine acetyltransferase 6B	ENSG00000156650	35
KAT6A / Q92794 / lysine acetyltransferase 6A	ENSG00000083168	34
KAT7 / O95251 / lysine acetyltransferase 7	ENSG00000136504	32
KAT8 / Q9H7Z6 / lysine acetyltransferase 8	ENSG00000103510	31

Protein motifs (from Interpro)

Interpro ID	Name
IPR000953	Chromo/chromo shadow domain
IPR002717	Histone acetyltransferase domain, MYST-type
IPR016181	Acyl-CoA N-acyltransferase
IPR016197	Chromo-like domain superfamily
IPR025995	RNA binding activity-knot of a chromodomain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0000729	DNA double-strand break processing	TAS
biological_process	GO:0000731	DNA synthesis involved in DNA repair	TAS
biological_process	GO:0000732	strand displacement	TAS
biological_process	GO:0006260	DNA replication	TAS
biological_process	GO:0006302	double-strand break repair	IMP
biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	TAS
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA
biological_process	GO:0010212	response to ionizing radiation	IDA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016573	histone acetylation	IEA
biological_process	GO:0030521	androgen receptor signaling pathway	NAS
biological_process	GO:0032703	negative regulation of interleukin-2 production	IDA
biological_process	GO:0040008	regulation of growth	IEA
biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IDA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	NAS
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0071392	cellular response to estradiol stimulus	IDA
biological_process	GO:1901796	regulation of signal transduction by p53 class mediator	TAS
biological_process	GO:1901985	positive regulation of protein acetylation	IDA
biological_process	GO:1904837	beta-catenin-TCF complex assembly	TAS
cellular_component	GO:0000812	Swr1 complex	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IDA
cellular_component	GO:0005667	transcription factor complex	IEA
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0032777	Piccolo NuA4 histone acetyltransferase complex	IDA
cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0003713	transcription coactivator activity	TAS
molecular_function	GO:0004402	histone acetyltransferase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016407	acetyltransferase activity	TAS
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016746	transferase activity, transferring acyl groups	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0050681	androgen receptor binding	NAS
molecular_function	GO:0070491	repressing transcription factor binding	IPI

Pathways (from Reactome)

Pathway description

Formation of the beta-catenin:TCF transactivating complex

DNA Damage/Telomere Stress Induced Senescence

HATs acetylate histones

HDR through Single Strand Annealing (SSA)

HDR through Homologous Recombination (HRR)

Sensing of DNA Double Strand Breaks

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Resolution of D-loop Structures through Holliday Junction Intermediates

Nonhomologous End-Joining (NHEJ)

Homologous DNA Pairing and Strand Exchange

Processing of DNA double-strand break ends

Presynaptic phase of homologous DNA pairing and strand exchange

Regulation of TP53 Activity through Phosphorylation

G2/M DNA damage checkpoint

Estrogen-dependent gene expression

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000011485	PPP5C / P53041 / protein phosphatase 5 catalytic subunit	/ reaction
ENSG00000127663	KDM4B / O94953 / lysine demethylase 4B	/ reaction / complex
ENSG00000080345	RIF1 / Q5UIP0 / replication timing regulatory factor 1	/ complex / reaction
ENSG00000136492	BRIP1 / Q9BX63 / BRCA1 interacting protein C-terminal helicase 1	/ reaction / complex
ENSG00000104320	NBN / nibrin / O60934	/ reaction / complex
ENSG00000138376	BARD1 / Q99728 / BRCA1 associated RING domain 1	/ complex / reaction
ENSG00000067369	Q12888 / TP53BP1 / tumor protein p53 binding protein 1	/ complex / reaction
ENSG00000138795	LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1	/ reaction / complex
ENSG00000166313	APBB1 / O00213 / amyloid beta precursor protein binding family B member 1	/ complex / reaction
ENSG00000109685	NSD2 / O96028 / nuclear receptor binding SET domain protein 2	/ complex / reaction
ENSG00000149311	ATM / Q13315 / ATM serine/threonine kinase	/ complex
ENSG00000148737	Q9NQB0 / TCF7L2 / transcription factor 7 like 2	/ complex / reaction
ENSG00000020922	MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease	/ reaction / complex
ENSG00000183765	CHEK2 / O96017 / checkpoint kinase 2	/ reaction / complex
ENSG00000163961	Q8IYW5 / RNF168 / ring finger protein 168	/ complex / reaction
ENSG00000175792	Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1	/ reaction / complex
ENSG00000112130	RNF8 / O76064 / ring finger protein 8	/ reaction / complex
ENSG00000106399	RPA3 / P35244 / replication protein A3	/ complex / reaction
ENSG00000178966	RMI1 / Q9H9A7 / RecQ mediated genome instability 1	/ complex / reaction
ENSG00000138346	DNA2 / P51530 / DNA replication helicase/nuclease 2	/ complex / reaction
ENSG00000157212	PAXIP1 / Q6ZW49 / PAX interacting protein 1	/ complex / reaction
ENSG00000113522	RAD50 / Q92878 / RAD50 double strand break repair protein	/ reaction / complex
ENSG00000177302	TOP3A / Q13472 / DNA topoisomerase III alpha	/ complex / reaction
ENSG00000175643	RMI2 / Q96E14 / RecQ mediated genome instability 2	/ reaction / complex
ENSG00000169139	Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2	/ complex / reaction
ENSG00000165392	WRN / Q14191 / Werner syndrome RecQ like helicase	/ complex / reaction
ENSG00000137337	MDC1 / Q14676 / mediator of DNA damage checkpoint 1	/ complex / reaction
ENSG00000174371	EXO1 / Q9UQ84 / exonuclease 1	/ reaction / complex
ENSG00000101773	RBBP8 / Q99708 / RB binding protein 8, endonuclease	/ reaction / complex
ENSG00000116030	SUMO1 / P63165 / small ubiquitin-like modifier 1	/ reaction / complex
ENSG00000164053	ATRIP / Q8WXE1 / ATR interacting protein	/ reaction / complex
ENSG00000197299	BLM / P54132 / Bloom syndrome RecQ like helicase	/ reaction / complex
ENSG00000168148	Q16695 / HIST3H3 / histone cluster 3 H3	/ complex / reaction
ENSG00000132383	RPA1 / P27694 / replication protein A1	/ complex / reaction
ENSG00000175054	ATR / Q13535 / ATR serine/threonine kinase	/ complex / reaction
ENSG00000177889	UBE2N / P61088 / ubiquitin conjugating enzyme E2 N	/ reaction / complex
ENSG00000012048	BRCA1 / P38398 / BRCA1, DNA repair associated	/ complex / reaction
ENSG00000188486	H2AFX / P16104 / H2A histone family member X	/ complex / reaction
ENSG00000103275	UBE2I / P63279 / ubiquitin conjugating enzyme E2 I	/ reaction
ENSG00000128731	HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2	/ complex / reaction
ENSG00000105229	PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4	/ complex / reaction
ENSG00000276180	P62805 / HIST1H4I / histone cluster 1 H4 family member i	/ complex / reaction
ENSG00000188612	SUMO2 / P61956 / small ubiquitin-like modifier 2	/ reaction / complex
ENSG00000123374	CDK2 / P24941 / cyclin dependent kinase 2	/ reaction / complex
ENSG00000117748	RPA2 / P15927 / replication protein A2	/ complex / reaction
ENSG00000196367	TRRAP / Q9Y4A5 / transformation/transcription domain associated protein	/ complex / reaction
ENSG00000163322	Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit	/ complex / reaction
ENSG00000196419	XRCC6 / P12956 / X-ray repair cross complementing 6	/ reaction
ENSG00000168036	CTNNB1 / P35222 / catenin beta 1	/ complex / reaction
ENSG00000152457	Q96SD1 / DCLRE1C / DNA cross-link repair 1C	/ reaction / complex
ENSG00000107643	MAPK8 / P45983 / mitogen-activated protein kinase 8	/ complex / reaction
ENSG00000158161	EYA3 / Q99504 / EYA transcriptional coactivator and phosphatase 3	/ reaction
ENSG00000066135	KDM4A / O75164 / lysine demethylase 4A	/ reaction / complex
ENSG00000079246	XRCC5 / P13010 / X-ray repair cross complementing 5	/ reaction
ENSG00000087206	UIMC1 / Q96RL1 / ubiquitin interaction motif containing 1	/ complex / reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr