ENSG00000174371


Homo sapiens

Features
Gene ID: ENSG00000174371
  
Biological name :EXO1
  
Synonyms : EXO1 / exonuclease 1 / Q9UQ84
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q43
Gene start: 241847967
Gene end: 241895148
  
Corresponding Affymetrix probe sets: 204603_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429720
Ensembl peptide - ENSP00000428326
Ensembl peptide - ENSP00000430082
Ensembl peptide - ENSP00000430251
Ensembl peptide - ENSP00000311873
Ensembl peptide - ENSP00000355506
Ensembl peptide - ENSP00000406652
Ensembl peptide - ENSP00000412041
Ensembl peptide - ENSP00000415531
NCBI entrez gene - 9156     See in Manteia.
OMIM - 606063
RefSeq - XM_017002793
RefSeq - NM_001319224
RefSeq - NM_003686
RefSeq - NM_006027
RefSeq - NM_130398
RefSeq - XM_006711840
RefSeq - XM_011544321
RefSeq - XM_011544322
RefSeq - XM_011544323
RefSeq - XM_011544324
RefSeq Peptide - NP_569082
RefSeq Peptide - NP_001306153
RefSeq Peptide - NP_003677
RefSeq Peptide - NP_006018
swissprot - Q5T398
swissprot - Q5T399
swissprot - Q9UQ84
swissprot - E5RGY3
swissprot - Q5T397
swissprot - E5RHK1
swissprot - H0YAZ2
Ensembl - ENSG00000174371
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exo1ENSDARG00000056832Danio rerio
 EXO1ENSGALG00000010748Gallus gallus
 Exo1ENSMUSG00000039748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR019974  XPG conserved site
 IPR029060  PIN-like domain superfamily
 IPR032641  Exonuclease 1
 IPR036279  5"-3" exonuclease, C-terminal domain superfamily
 IPR037315  Exonuclease-1, H3TH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000731 DNA synthesis involved in DNA repair TAS
 biological_processGO:0000732 strand displacement TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin IEA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006298 mismatch repair TAS
 biological_processGO:0006310 DNA recombination TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IEA
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0090656 t-circle formation TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004523 RNA-DNA hybrid ribonuclease activity TAS
 molecular_functionGO:0004527 exonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008409 5"-3" exonuclease activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0035312 5"-3" exodeoxyribonuclease activity IDA
 molecular_functionGO:0045145 single-stranded DNA 5"-3" exodeoxyribonuclease activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048256 flap endonuclease activity IDA
 molecular_functionGO:0051908 double-stranded DNA 5"-3" exodeoxyribonuclease activity IDA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136492 BRIP1 / Q9BX63 / BRCA1 interacting protein C-terminal helicase 1  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000138376 BARD1 / Q99728 / BRCA1 associated RING domain 1  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction / complex
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / reaction / complex
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / complex / reaction
 ENSG00000164053 ATRIP / Q8WXE1 / ATR interacting protein  / reaction / complex
 ENSG00000113318 MSH3 / P20585 / mutS homolog 3  / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction / complex
 ENSG00000122512 PMS2 / P54278 / PMS1 homolog 2, mismatch repair system component  / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000116062 MSH6 / P52701 / mutS homolog 6  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000095002 MSH2 / P43246 / mutS homolog 2  / reaction
 ENSG00000076242 MLH1 / P40692 / mutL homolog 1  / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction






 

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