ENSMUSG00000039748


Mus musculus

Features
Gene ID: ENSMUSG00000039748
  
Biological name :Exo1
  
Synonyms : Exo1 / Exonuclease 1 / Q9QZ11
  
Possible biological names infered from orthology : Q9UQ84
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H4
Gene start: 175880581
Gene end: 175913489
  
Corresponding Affymetrix probe sets: 10352048 (MoGene1.0st)   1418026_at (Mouse Genome 430 2.0 Array)   1418027_at (Mouse Genome 430 2.0 Array)   1430225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039376
Ensembl peptide - ENSMUSP00000142091
Ensembl peptide - ENSMUSP00000141870
Ensembl peptide - ENSMUSP00000141770
Ensembl peptide - ENSMUSP00000141624
Ensembl peptide - ENSMUSP00000141568
Ensembl peptide - ENSMUSP00000141526
Ensembl peptide - ENSMUSP00000141316
NCBI entrez gene - 26909     See in Manteia.
MGI - MGI:1349427
RefSeq - NM_012012
RefSeq - XM_006496862
RefSeq - XM_006496863
RefSeq Peptide - NP_036142
swissprot - A0A0A6YWF4
swissprot - A0A0A6YXQ6
swissprot - Q9QZ11
swissprot - A0A0A6YVY2
swissprot - A0A0A6YX74
swissprot - A0A0A6YWZ8
swissprot - A0A0A6YWN5
swissprot - A0A0A6YWI7
Ensembl - ENSMUSG00000039748
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exo1ENSDARG00000056832Danio rerio
 EXO1ENSGALG00000010748Gallus gallus
 EXO1ENSG00000174371Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR019974  XPG conserved site
 IPR029060  PIN-like domain superfamily
 IPR032641  Exonuclease 1
 IPR036279  5"-3" exonuclease, C-terminal domain superfamily
 IPR037315  Exonuclease-1, H3TH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin IMP
 biological_processGO:0006139 nucleobase-containing compound metabolic process ISO
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IMP
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008409 5"-3" exonuclease activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0035312 5"-3" exodeoxyribonuclease activity IEA
 molecular_functionGO:0045145 single-stranded DNA 5"-3" exodeoxyribonuclease activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048256 flap endonuclease activity IEA
 molecular_functionGO:0051908 double-stranded DNA 5"-3" exodeoxyribonuclease activity IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Exo1tm1Wed/Exo1tm1Wed,Ightm4.1Mnz/Igh+,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129 * C57BL/6 * CBA/JNCrlj * SJL

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Exo1tm1Wed/Exo1tm1Wed,Ightm4.1Mnz/Igh+
Genetic Background: involves: C57BL/6 * CBA/JNCrlj * SJL

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008966 abnormal chiasmata formation "atypical contact between nonsister chromatids of homologous chromosomes during meiosis I, precluding formation of the expected number of cross-shaped configurations representing recombination events" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008967 absent chiasmata formation "during meiosis I there are no observable cross-over regions where nonsister chromatids of homologous chromosomes recombine with each other" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009564 abnormal meiotic configurations "uncharacteristic chromosome arrangement produced by anomalous chromosome pairing and chiasma formation from prophase to metaphase of meiosis I due to abnormal chromosome structure and necessary to produce functional gametes" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009761 abnormal meiotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009797 abnormal mismatch repair "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0010094 abnormal chromosome stability "anomaly in the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an reduced rate of loss of heterozygosity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed
Genetic Background: involves: 129 * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Exo1tm2Wed/Exo1tm2Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000005370 Msh6 / P54276 / DNA mismatch repair protein Msh6 / P52701* / mutS homolog 6*  / reaction
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / reaction / complex
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000024151 Msh2 / P43247 / DNA mismatch repair protein Msh2 / P43246* / mutS homolog 2*  / reaction
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / reaction / complex
 ENSMUSG00000032498 Mlh1 / Q9JK91 / DNA mismatch repair protein Mlh1 / P40692* / mutL homolog 1*  / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000079109 Pms2 / PMS1 homolog2, mismatch repair system component / P54278*  / reaction






 

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