ENSMUSG00000020380


Mus musculus

Features
Gene ID: ENSMUSG00000020380
  
Biological name :Rad50
  
Synonyms : Rad50 / RAD50 double strand break repair protein
  
Possible biological names infered from orthology : AC116366.3 / Q92878
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 53649519
Gene end: 53707319
  
Corresponding Affymetrix probe sets: 10385842 (MoGene1.0st)   1422630_at (Mouse Genome 430 2.0 Array)   1425939_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020649
Ensembl peptide - ENSMUSP00000120869
Ensembl peptide - ENSMUSP00000119618
NCBI entrez gene - 19360     See in Manteia.
MGI - MGI:109292
RefSeq - NM_009012
RefSeq Peptide - NP_033038
swissprot - E9PUJ2
swissprot - A8Y5I3
swissprot - Q5SV02
Ensembl - ENSMUSG00000020380
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad50ENSDARG00000038917Danio rerio
 ENSGALG00000006794Gallus gallus
 AC116366.3ENSG00000283782Homo sapiens
 RAD50ENSG00000113522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004584  DNA repair protein Rad50, eukaryotes
 IPR013134  RAD50, zinc hook
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006281 DNA repair IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0030870 Mre11 complex IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000175 absent bone marrow cell "lack of cells that make up the core cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Rad50tm3Jpt/Rad50tm4.1Jpt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rad50tm1Jpt/Rad50tm3Jpt,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Rad50tm1Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atm+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11a+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Tg(BCL2)22Wehi/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nbntm2.1Jpt/Nbntm2.1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * 129/Sv

Allelic Composition: Nbntm2.1Jpt/Nbn+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * 129/Sv

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rlimtm1.2Inba/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rad50tm4Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm1Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atm+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11a+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Tg(BCL2)22Wehi/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi

Allelic Composition: Chek2tm1Mak/Chek2tm1Mak,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Atmtm1Awb/Atm+,Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Rad50tm4.1Jpt/Rad50+,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002328 abnormal airway resistance "anomaly in the opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rlimtm1.2Inba/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rlimtm1.2Inba/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rlimtm1.2Inba/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rlimtm1.2Inba/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0003134 increased number of late pro-B cells "greater number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, J:91592, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rad50tm4Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Atmtm1Awb/Atm+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004849 abnormal testis size "anomaly in the size of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atm+,Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rlimtm1.2Inba/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J

Allelic Composition: Rad50tm2.1Flv/Rad50tm2.2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nbntm2.1Jpt/Nbntm2.1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * 129/Sv

Allelic Composition: Nbntm2.1Jpt/Nbn+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * 129/Sv

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rad50tm4Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Rad50tm2.1Flv/Rad50tm2.2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Gfra1tm2Jmi/Gfra1tm1(cre/ERT2)Sjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J

Allelic Composition: Rad50tm2.1Flv/Rad50tm2.2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Rad50tm4.1Flv/Rad50tm4.1Flv
Genetic Background: B6.129S6-Rad50tm4.1Flv

Allelic Composition: Rad50tm3.1Flv/Rad50tm3.1Flv
Genetic Background: B6.129S6-Rad50tm3.1Flv

Allelic Composition: Rad50tm2.1Flv/Rad50tm2.1Flv
Genetic Background: B6.129S6-Rad50tm2.1Flv

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Rad50tm4.1Flv/Rad50tm4.1Flv
Genetic Background: B6.129S6-Rad50tm4.1Flv

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J

Allelic Composition: Rad50tm2.1Flv/Rad50tm2.2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Rad50tm3.1Flv/Rad50tm3.1Flv
Genetic Background: B6.129S6-Rad50tm3.1Flv

Allelic Composition: Rad50tm2.1Flv/Rad50tm2.1Flv
Genetic Background: B6.129S6-Rad50tm2.1Flv

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Rad50tm4.1Flv/Rad50tm4.1Flv
Genetic Background: B6.129S6-Rad50tm4.1Flv

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J

Allelic Composition: Rad50tm2.1Flv/Rad50tm2.2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Rad50tm4.1Flv/Rad50tm4.1Flv
Genetic Background: B6.129S6-Rad50tm4.1Flv

Allelic Composition: Rad50tm3.1Flv/Rad50tm3.1Flv
Genetic Background: B6.129S6-Rad50tm3.1Flv

Allelic Composition: Rad50tm2.1Flv/Rad50tm2.1Flv
Genetic Background: B6.129S6-Rad50tm2.1Flv

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Rad50tm2.1Flv/Rad50tm2.2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Atmtm1Awb/Atm+,Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0010054 hepatoblastoma "a malignant neoplasm occurring primarily in the liver and composed of tissue resembling embryonic or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Rad50tm3Jpt/Rad50tm4.1Jpt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rad50tm1Jpt/Rad50tm3Jpt,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rlimtm1.2Inba/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Rad50tm5Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rad50tm1Jpt/Rad50tm4.1Jpt
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0011276 increased tail pigmentation "visually detectable excess of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Rad50tm1Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atm+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11a+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Chek2tm1Mak/Chek2tm1Mak,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / complex / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / reaction / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / complex / reaction
 ENSMUSG00000031583 Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*  / complex / reaction
 ENSMUSG00000037032 Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*  / reaction / complex
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / complex / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / reaction / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / reaction / complex
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / reaction / complex
 ENSMUSG00000034206 Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*  / complex / reaction
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex / reaction
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / complex / reaction
 ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex / reaction
 ENSMUSG00000028886 Eya3 / P97480 / Eyes absent homolog 3 / Q99504* / EYA transcriptional coactivator and phosphatase 3*  / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction / complex
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction / complex
 ENSMUSG00000051768 Xrcc1 / Q60596 / X-ray repair complementing defective repair in Chinese hamster cells 1 / P18887* / X-ray repair cross complementing 1*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction






 

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