ENSMUSG00000030451


Mus musculus

Features
Gene ID: ENSMUSG00000030451
  
Biological name :Herc2
  
Synonyms : E3 ubiquitin-protein ligase HERC2 / Herc2 / Q4U2R1
  
Possible biological names infered from orthology : HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B5
Gene start: 56050196
Gene end: 56231800
  
Corresponding Affymetrix probe sets: 10553646 (MoGene1.0st)   1426491_at (Mouse Genome 430 2.0 Array)   1427625_a_at (Mouse Genome 430 2.0 Array)   1444228_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145560
Ensembl peptide - ENSMUSP00000146182
Ensembl peptide - ENSMUSP00000145997
Ensembl peptide - ENSMUSP00000145771
Ensembl peptide - ENSMUSP00000075579
Ensembl peptide - ENSMUSP00000131573
NCBI entrez gene - 15204     See in Manteia.
MGI - MGI:103234
RefSeq - XM_006540637
RefSeq - XM_006540639
RefSeq - XM_006540638
RefSeq - NM_010418
RefSeq Peptide - NP_034548
swissprot - Q4U2R1
swissprot - A0A0U1RPZ3
swissprot - A0A0U1RNG9
swissprot - A0A0U1RP01
Ensembl - ENSMUSG00000030451
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 herc2ENSDARG00000073841Danio rerio
 HERC2ENSGALG00000016739Gallus gallus
 HERC2ENSG00000128731Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Herc1 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Q15751*ENSMUSG0000003866425
Herc6 / F2Z461 / E3 ISG15--protein ligase Herc6 / Q8IVU3* / HECT and RLD domain containing E3 ubiquitin protein ligase family member 6*ENSMUSG000000297984
Hectd3 / Q3U487 / E3 ubiquitin-protein ligase HECTD3 / Q5T447* / HECT domain E3 ubiquitin protein ligase 3*ENSMUSG000000468614
Herc4 / Q6PAV2 / Probable E3 ubiquitin-protein ligase HERC4 / Q5GLZ8* / HECT and RLD domain containing E3 ubiquitin protein ligase 4*ENSMUSG000000200644
Herc3 / HECT and RLD domain containing E3 ubiquitin protein ligase 3 / Q15034*ENSMUSG000000298044
Ube3a / O08759 / ubiquitin protein ligase E3A / Q05086*ENSMUSG000000253262
Hectd2 / Q8CDU6 / Probable E3 ubiquitin-protein ligase HECTD2 / Q5U5R9* / HECT domain E3 ubiquitin protein ligase 2*ENSMUSG000000411802
Rccd1 / Q8BTU7 / RCC1 domain-containing protein 1 / A6NED2* / RCC1 domain containing 1*ENSMUSG000000389302


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000433  Zinc finger, ZZ-type
 IPR000569  HECT domain
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR004939  APC10/DOC domain
 IPR006624  Beta-propeller repeat TECPR
 IPR008979  Galactose-binding-like domain superfamily
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR010606  Mib-herc2
 IPR014722  Ribosomal protein L2, domain 2
 IPR016186  C-type lectin-like/link domain superfamily
 IPR021097  CPH domain
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily
 IPR037252  Mib/herc2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0032183 SUMO binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Herc2jdf2-1R/Herc2jdf2-1R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-2R/Herc2jdf2-2R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-9R/Herc2jdf2-9R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-10R/Herc2jdf2-10R
Genetic Background: Not Specified

Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Herc2jdf2-1R/Herc2jdf2-1R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-2R/Herc2jdf2-2R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Herc2jdf2-1R/Herc2jdf2-1R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-2R/Herc2jdf2-2R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Grxcr1mpc265H/Grxcr1mpc265H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Herc2jdf2-1R/Herc2jdf2-1R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-2R/Herc2jdf2-2R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-8R/Herc2jdf2-8R
Genetic Background: Not Specified

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Herc2jdf2-9R/Herc2jdf2-9R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-10R/Herc2jdf2-10R
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Herc2jdf2-2R/Herc2jdf2-2R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-7R/Herc2jdf2-7R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-5R/Herc2jdf2-5R
Genetic Background: Not Specified

Allelic Composition: Herc2jdf2-6R/Herc2jdf2-6R
Genetic Background: Not Specified

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Grxcr1mpc265H/Grxcr1mpc265H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / reaction / complex
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction / complex
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / complex / reaction
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / complex / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / reaction / complex
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / complex / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction






 

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