ENSMUSG00000025878


Mus musculus

Features
Gene ID: ENSMUSG00000025878
  
Biological name :Uimc1
  
Synonyms : ubiquitin interaction motif containing 1 / Uimc1
  
Possible biological names infered from orthology : Q96RL1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 55027880
Gene end: 55100300
  
Corresponding Affymetrix probe sets: 10409396 (MoGene1.0st)   1426829_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026997
Ensembl peptide - ENSMUSP00000122196
Ensembl peptide - ENSMUSP00000120935
Ensembl peptide - ENSMUSP00000097095
NCBI entrez gene - 20184     See in Manteia.
MGI - MGI:103185
RefSeq - XM_006517166
RefSeq - XM_011244499
RefSeq - XM_006517169
RefSeq - XM_006517167
RefSeq - NM_001293660
RefSeq - NM_011307
RefSeq Peptide - NP_001280589
RefSeq Peptide - NP_035437
swissprot - E9Q577
swissprot - A0A0R4J073
swissprot - A0A0R4J183
swissprot - E9PWM5
Ensembl - ENSMUSG00000025878
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX649250.1ENSDARG00000091187Danio rerio
 UIMC1ENSGALG00000001158Gallus gallus
 UIMC1ENSG00000087206Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003903  Ubiquitin interacting motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0070537 histone H2A K63-linked deubiquitination IEA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0070531 BRCA1-A complex IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Uimc1tm1.2Amj/Uimc1tm1.2Amj
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction / complex
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / reaction / complex
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex






 

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