ENSMUSG00000014074


Mus musculus

Features
Gene ID: ENSMUSG00000014074
  
Biological name :Rnf168
  
Synonyms : E3 ubiquitin-protein ligase RNF168 / Q80XJ2 / Rnf168
  
Possible biological names infered from orthology : Q8IYW5 / ring finger protein 168
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 32277459
Gene end: 32301434
  
Corresponding Affymetrix probe sets: 10435024 (MoGene1.0st)   1455585_at (Mouse Genome 430 2.0 Array)   1455586_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014218
Ensembl peptide - ENSMUSP00000126484
Ensembl peptide - ENSMUSP00000115807
NCBI entrez gene - 70238     See in Manteia.
MGI - MGI:1917488
RefSeq - NM_027355
RefSeq Peptide - NP_081631
swissprot - E9Q0M6
swissprot - E9PYW4
swissprot - Q80XJ2
Ensembl - ENSMUSG00000014074
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf168ENSDARG00000112483Danio rerio
 RNF168ENSGALG00000006392Gallus gallus
 Q8IYW5ENSG00000163961Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034725  E3 ubiquitin-protein ligase RNF168


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0033522 histone H2A ubiquitination IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0035518 histone H2A monoubiquitination IEA
 biological_processGO:0036351 histone H2A-K13 ubiquitination IEA
 biological_processGO:0036352 histone H2A-K15 ubiquitination IEA
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0070535 histone H2A K63-linked ubiquitination IEA
 biological_processGO:1903827 regulation of cellular protein localization IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 cellular_componentGO:1990391 DNA repair complex IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031491 nucleosome binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008759 abnormal T cell receptor delta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor delta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014127 increased thymoma incidence "greater than the expected number of a malignant neoplasm originating from the epithelial cells of the thymus, occurring in a specific population in a given time period; thymoma is an uncommon tumor linked with myasthenia gravis and other autoimmune diseases" [http://medical-dictionary.thefreedictionary.com/thymoma, http://www.cancer.gov/cancertopics/pdq/treatment/thymoma/patient/page1#_139]
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Allelic Composition: Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / reaction / complex
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / reaction / complex
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / complex / reaction
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction / complex
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / complex / reaction






 

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