ENSMUSG00000029521


Mus musculus

Features
Gene ID: ENSMUSG00000029521
  
Biological name :Chek2
  
Synonyms : Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2
  
Possible biological names infered from orthology : checkpoint kinase 2 / O96017
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 110839979
Gene end: 110874145
  
Corresponding Affymetrix probe sets: 10524266 (MoGene1.0st)   1422747_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142506
Ensembl peptide - ENSMUSP00000143558
Ensembl peptide - ENSMUSP00000066679
Ensembl peptide - ENSMUSP00000142475
NCBI entrez gene - 50883     See in Manteia.
MGI - MGI:1355321
RefSeq - XM_017320973
RefSeq - XM_006535067
RefSeq - XM_006535068
RefSeq - XM_006535069
RefSeq - XM_006535070
RefSeq - XM_006535071
RefSeq - XM_006535072
RefSeq - NM_016681
RefSeq Peptide - NP_057890
swissprot - A0A0G2JGG6
swissprot - A0A0G2JDU5
swissprot - A0A0G2JDS0
swissprot - Q543W6
swissprot - Q9Z265
Ensembl - ENSMUSG00000029521
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chek2ENSDARG00000025820Danio rerio
 CHEK2ENSGALG00000005695Gallus gallus
 CHEK2ENSG00000183765Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008984  SMAD/FHA domain superfamily
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0001302 replicative cell aging IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006975 DNA damage induced protein phosphorylation IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010332 response to gamma radiation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0044773 mitotic DNA damage checkpoint IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071480 cellular response to gamma radiation IMP
 biological_processGO:0072428 signal transduction involved in intra-S DNA damage checkpoint ISO
 biological_processGO:0090307 mitotic spindle assembly IEA
 biological_processGO:1903416 response to glycoside IEA
 biological_processGO:1903926 cellular response to bisphenol A IEA
 biological_processGO:2000002 negative regulation of DNA damage checkpoint IEA
 biological_processGO:2000210 positive regulation of anoikis IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016605 PML body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Brca1tm2Mak/Brca1tm2Mak,Tg(Wap-cre)11738Mam/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Brca1tm2Mak/Brca1tm2Mak,Chek2tm1Mak/Chek2tm1Mak,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chek2tm1Mak/Chek2tm1Mak,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003010 decreased mortality induced by ionizing radiation "reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88888]
Show

Allelic Composition: Ccna1tm1Coll/Ccna1+
Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * MF1)

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccna1tm1Coll/Ccna1+
Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * MF1)

Allelic Composition: Chek2tm1Mak/Chek2tm1Mak
Genetic Background: involves: 129P2/OlaHsd

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Cep63Gt(EUCE0251h11)Hmgu/Cep63Gt(EUCE0251h11)Hmgu,Chek2tm1Mak/Chek2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Brca1tm2Mak/Brca1tm2Mak,Chek2tm1Mak/Chek2tm1Mak,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Chek2tm1Mak/Chek2tm1Mak,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSMUSG00000032477 Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*  / reaction
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / complex / reaction
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction / complex
 ENSMUSG00000054387 Mdm4 / O35618 / transformed mouse 3T3 cell double minute 4 / O15151* / MDM4, p53 regulator*  / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / complex / reaction
 ENSMUSG00000044201 Cdc25c / P48967 / cell division cycle 25C / P30307*  / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction
 ENSMUSG00000006288 Ttc5 / Q99LG4 / tetratricopeptide repeat domain 5 / Q8N0Z6*  / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction






 

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