ENSDARG00000025820


Danio rerio

Features
Gene ID: ENSDARG00000025820
  
Biological name :chek2
  
Synonyms : checkpoint kinase 2 / chek2
  
Possible biological names infered from orthology : O96017 / Q9Z265 / Serine/threonine-protein kinase Chk2
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 10055980
Gene end: 10082244
  
Corresponding Affymetrix probe sets: Dr.4877.1.S1_at (Zebrafish Array)   NM_200045_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000036490
NCBI entrez gene - 336998     See in Manteia.
RefSeq - NM_200045
RefSeq - XM_005165030
RefSeq Peptide - NP_956339
swissprot - B0V1J5
ZFIN ID - ZDB-GENE-030131-8942
Ensembl - ENSDARG00000025820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHEK2ENSGALG00000005695Gallus gallus
 CHEK2ENSG00000183765Homo sapiens
 Chek2ENSMUSG00000029521Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008984  SMAD/FHA domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR020636  Calcium/calmodulin-dependent/calcium-dependent protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0042770 signal transduction in response to DNA damage IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0044773 mitotic DNA damage checkpoint IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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