ENSGALG00000005695


Gallus gallus

Features
Gene ID: ENSGALG00000005695
  
Biological name :CHEK2
  
Synonyms : checkpoint kinase 2 / CHEK2
  
Possible biological names infered from orthology : O96017 / Q9Z265 / Serine/threonine-protein kinase Chk2
  
Species: Gallus gallus
  
Chr. number: 15
Strand: -1
Band:
Gene start: 7725718
Gene end: 7738830
  
Corresponding Affymetrix probe sets: Gga.2517.1.S1_at (Chicken Array)   Gga.2517.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009122
Ensembl peptide - ENSGALP00000049784
NCBI entrez gene - 768913     See in Manteia.
RefSeq - NM_001080107
RefSeq - XM_015275342
RefSeq Peptide - NP_001073576
swissprot - A1EAT1
swissprot - A0A1D5PAM1
Ensembl - ENSGALG00000005695
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chek2ENSDARG00000025820Danio rerio
 CHEK2ENSG00000183765Homo sapiens
 Chek2ENSMUSG00000029521Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008984  SMAD/FHA domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR020636  Calcium/calmodulin-dependent/calcium-dependent protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination TAS
 biological_processGO:0001302 replicative cell aging IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0072428 signal transduction involved in intra-S DNA damage checkpoint IEA
 biological_processGO:0090307 mitotic spindle assembly IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Regulation of TP53 Degradation
G2/M DNA damage checkpoint
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
ATM mediated phosphorylation of repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSGALG00000005695 CHEK2 / checkpoint kinase 2 / O96017* / Q9Z265* / Serine/threonine-protein kinase Chk2 *  / complex / reaction
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / reaction / complex
 ENSGALG00000009942 MDM2 / MDM2 proto-oncogene / P23804* / Q00987* / E3 ubiquitin-protein ligase Mdm2 *  / reaction
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSGALG00000038469 CDC25A / cell division cycle 25A / P30304* / P48964* / M-phase inducer phosphatase 1 *  / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSGALG00000042491 P62801 / Histone H4   / reaction / complex
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / reaction / complex
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / reaction / complex
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex






 

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