ENSGALG00000045705


Gallus gallus

Features
Gene ID: ENSGALG00000045705
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : H2AFX / H2A histone family member X / Histone H2AX / P16104 / P27661
  
Species: Gallus gallus
  
Chr. number: 24
Strand: 1
Band:
Gene start: 35477
Gene end: 36312
  
Corresponding Affymetrix probe sets: Gga.11949.1.S1_at (Chicken Array)   GgaAffx.23666.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060498
NCBI entrez gene - 100857391     See in Manteia.
RefSeq - XM_004947917
swissprot - A0A1L1RNY8
Ensembl - ENSGALG00000045705
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR354435.3ENSDARG00000111536Danio rerio
 CR354435.4ENSDARG00000113707Danio rerio
 CU302436.3ENSDARG00000113800Danio rerio
 CU457819.1ENSDARG00000100279Danio rerio
 FP236812.2ENSDARG00000109926Danio rerio
 FP236812.4ENSDARG00000115875Danio rerio
 FP340257.1ENSDARG00000100024Danio rerio
 h2afxENSDARG00000029406Danio rerio
 h2afx1ENSDARG00000068995Danio rerio
 hist1h2a1ENSDARG00000109458Danio rerio
 hist1h2a10ENSDARG00000105366Danio rerio
 hist1h2a10ENSDARG00000112840Danio rerio
 hist1h2a11ENSDARG00000105444Danio rerio
 hist1h2a11ENSDARG00000088686Danio rerio
 hist1h2a11ENSDARG00000100906Danio rerio
 hist1h2a11ENSDARG00000086552Danio rerio
 hist1h2a11ENSDARG00000098595Danio rerio
 hist1h2a2ENSDARG00000112593Danio rerio
 hist1h2a2ENSDARG00000110809Danio rerio
 hist1h2a2ENSDARG00000111648Danio rerio
 hist1h2a2ENSDARG00000109755Danio rerio
 hist1h2a2ENSDARG00000070280Danio rerio
 hist1h2a4ENSDARG00000105314Danio rerio
 hist1h2a4ENSDARG00000051736Danio rerio
 hist1h2a4ENSDARG00000113399Danio rerio
 hist1h2a4ENSDARG00000103015Danio rerio
 hist1h2a4ENSDARG00000105400Danio rerio
 hist1h2a4ENSDARG00000099123Danio rerio
 hist1h2a5ENSDARG00000114133Danio rerio
 si:ch1073-153i20.5ENSDARG00000105478Danio rerio
 si:ch211-113a14.19ENSDARG00000113481Danio rerio
 H2AFXENSG00000188486Homo sapiens
 H2afxENSMUSG00000049932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P02263 / H2A-VII / Histone H2A-IV / H2AFJ* / Q8R1M2* / Q9BTM1* / Histone H2A.J * / H2A histone family member J*ENSGALG0000003264585
P02263 / H2A-VII / Histone H2A-IV / H2AFJ* / Q8R1M2* / Q9BTM1* / Histone H2A.J * / H2A histone family member J*ENSGALG0000002994185
P02263 / H2A-VII / Histone H2A-IV / H2AFJ* / Q8R1M2* / Q9BTM1* / Histone H2A.J * / H2A histone family member J*ENSGALG0000002711385
H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSGALG0000002644985
P02263 / H2A-VII / Histone H2A-IV / H2AFJ* / Q8R1M2* / Q9BTM1* / Histone H2A.J * / H2A histone family member J*ENSGALG0000003157185
P02263 / H2A-VII / Histone H2A-IV / H2AFJ* / Q8R1M2* / Q9BTM1* / Histone H2A.J * / H2A histone family member J*ENSGALG0000002731585
P02263 / H2A-VII / Histone H2A-IV / H2AFJ* / Q8R1M2* / Q9BTM1* / Histone H2A.J * / H2A histone family member J*ENSGALG0000003571585
P02263 / H2A-VII / Histone H2A-IV / H2AFJ* / Q8R1M2* / Q9BTM1* / Histone H2A.J * / H2A histone family member J*ENSGALG0000002837285
H2AFJ / histone H2A.J / Q6GSS7* / Q16777* / Q64523* / Q6FI13* / HIST2H2AC* / HIST2H2AA3* / Hist2h2aa1* / HIST2H2AA4* / Hist2h2aa2* / Histone H2A type 2-C * / Histone H2A type 2-A * / histo...ENSGALG0000003834383
ENSGALG0000001677161
H2AFY2 / H2A histone family member Y2 / Q8CCK0* / Q9P0M6* / Core histone macro-H2A.2 *ENSGALG0000000479460
H2AFY / O93327 / Core histone macro-H2A.1 / Q9QZQ8* / O75367* / H2A histone family member Y*ENSGALG0000004014159
ENSGALG0000001677058
H2AFB1* / H2AFB2* / H2AFB3* / P0C5Z0* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSGALG0000001560937


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000777 EYA3 / EYA transcriptional coactivator and phosphatase 3 / P97480* / Q99504* / Eyes absent homolog 3 *  / reaction
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / reaction / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000005695 CHEK2 / checkpoint kinase 2 / O96017* / Q9Z265* / Serine/threonine-protein kinase Chk2 *  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / reaction / complex
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction / complex
 ENSGALG00000012484 RIF1 / E1C2U2 / Telomere-associated protein RIF1 / Q6PR54* / Q5UIP0* / replication timing regulatory factor 1*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000042491 P62801 / Histone H4   / complex
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / complex / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000006109 MAPK8 / mitogen-activated protein kinase 8 / P45983* / Q91Y86*  / reaction / complex
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex






 

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