ENSGALG00000023256


Gallus gallus

Features
Gene ID: ENSGALG00000023256
  
Biological name :RNF8
  
Synonyms : ring finger protein 8 / RNF8
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase RNF8 / Gm28043 / O76064 / Q8VC56
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 30272647
Gene end: 30284458
  
Corresponding Affymetrix probe sets: GgaAffx.6386.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037382
Ensembl peptide - ENSGALP00000055529
Ensembl peptide - ENSGALP00000045533
NCBI entrez gene - 421435     See in Manteia.
RefSeq - XM_004935386
RefSeq - XM_015283790
RefSeq - XM_015283791
RefSeq - XM_419487
swissprot - A0A1D5PRK2
swissprot - A0A1D5NYS3
swissprot - E1C4A8
Ensembl - ENSGALG00000023256
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf8ENSDARG00000044949Danio rerio
 RNF8ENSG00000112130Homo sapiens
 Gm28043ENSMUSG00000098374Mus musculus
 Rnf8ENSMUSG00000090083Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001841  Zinc finger, RING-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0033522 histone H2A ubiquitination IEA
 biological_processGO:0033523 histone H2B ubiquitination IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0070535 histone H2A K63-linked ubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / complex / reaction
 ENSGALG00000005695 CHEK2 / checkpoint kinase 2 / O96017* / Q9Z265* / Serine/threonine-protein kinase Chk2 *  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSGALG00000012484 RIF1 / E1C2U2 / Telomere-associated protein RIF1 / Q6PR54* / Q5UIP0* / replication timing regulatory factor 1*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000042491 P62801 / Histone H4   / complex / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / complex / reaction
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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