ENSG00000112130


Homo sapiens

Features
Gene ID: ENSG00000112130
  
Biological name :RNF8
  
Synonyms : O76064 / ring finger protein 8 / RNF8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.2
Gene start: 37353972
Gene end: 37394738
  
Corresponding Affymetrix probe sets: 203160_s_at (Human Genome U133 Plus 2.0 Array)   203161_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419859
Ensembl peptide - ENSP00000418879
Ensembl peptide - ENSP00000420268
Ensembl peptide - ENSP00000229866
Ensembl peptide - ENSP00000362578
Ensembl peptide - ENSP00000417599
Ensembl peptide - ENSP00000417736
NCBI entrez gene - 9025     See in Manteia.
OMIM - 611685
RefSeq - XM_017011464
RefSeq - NM_003958
RefSeq - NM_183078
RefSeq - XM_006715241
RefSeq - XM_006715242
RefSeq - XM_017011462
RefSeq - XM_017011463
RefSeq Peptide - NP_898901
RefSeq Peptide - NP_003949
swissprot - F8WEW6
swissprot - O76064
swissprot - C9J858
swissprot - H7C4L7
swissprot - F8WDH8
Ensembl - ENSG00000112130
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf8ENSDARG00000044949Danio rerio
 RNF8ENSGALG00000023256Gallus gallus
 Gm28043ENSMUSG00000098374Mus musculus
 Rnf8ENSMUSG00000090083Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001841  Zinc finger, RING-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017335  E3 ubiquitin-protein ligase RNF8
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IDA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007286 spermatid development ISS
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0033522 histone H2A ubiquitination IDA
 biological_processGO:0033523 histone H2B ubiquitination ISS
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IMP
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins ISS
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0043486 histone exchange ISS
 biological_processGO:0045190 isotype switching ISS
 biological_processGO:0045739 positive regulation of DNA repair IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0070534 protein K63-linked ubiquitination IDA
 biological_processGO:0070535 histone H2A K63-linked ubiquitination IMP
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0000781 chromosome, telomeric region ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0035861 site of double-strand break IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000011485 PPP5C / P53041 / protein phosphatase 5 catalytic subunit  / reaction
 ENSG00000127663 KDM4B / O94953 / lysine demethylase 4B  / reaction / complex
 ENSG00000157212 PAXIP1 / Q6ZW49 / PAX interacting protein 1  / complex / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / complex / reaction
 ENSG00000080345 RIF1 / Q5UIP0 / replication timing regulatory factor 1  / reaction / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / complex
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction / complex
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / complex / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction / complex
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / complex / reaction
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000163322 Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit  / reaction / complex
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex / reaction
 ENSG00000066135 KDM4A / O75164 / lysine demethylase 4A  / complex / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / reaction / complex
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction
 ENSG00000087206 UIMC1 / Q96RL1 / ubiquitin interaction motif containing 1  / reaction / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr