ENSG00000079246


Homo sapiens

Features
Gene ID: ENSG00000079246
  
Biological name :XRCC5
  
Synonyms : P13010 / X-ray repair cross complementing 5 / XRCC5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q35
Gene start: 216107464
Gene end: 216206303
  
Corresponding Affymetrix probe sets: 208642_s_at (Human Genome U133 Plus 2.0 Array)   208643_s_at (Human Genome U133 Plus 2.0 Array)   232633_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395108
Ensembl peptide - ENSP00000401318
Ensembl peptide - ENSP00000375977
Ensembl peptide - ENSP00000375978
NCBI entrez gene - 7520     See in Manteia.
OMIM - 194364
RefSeq - NM_021141
RefSeq Peptide - NP_066964
swissprot - C9JZ81
swissprot - H7C0H9
swissprot - P13010
Ensembl - ENSG00000079246
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrcc5ENSDARG00000099298Danio rerio
 XRCC5ENSGALG00000011492Gallus gallus
 Xrcc5ENSMUSG00000026187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR005160  Ku70/Ku80 C-terminal arm
 IPR005161  Ku70/Ku80, N-terminal alpha/beta
 IPR006164  Ku70/Ku80 beta-barrel domain
 IPR014893  Ku, C-terminal
 IPR016194  SPOC-like, C-terminal domain superfamily
 IPR024193  Ku80
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR036494  Ku, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006310 DNA recombination TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0032204 regulation of telomere maintenance TAS
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043085 positive regulation of catalytic activity TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IMP
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0051973 positive regulation of telomerase activity TAS
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:0070198 protein localization to chromosome, telomeric region TAS
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071475 cellular hyperosmotic salinity response IEA
 biological_processGO:0071480 cellular response to gamma radiation IDA
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:0075713 establishment of integrated proviral latency TAS
 biological_processGO:1904430 negative regulation of t-circle formation IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0000783 nuclear telomere cap complex TAS
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0032993 protein-DNA complex IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0043564 Ku70:Ku80 complex TAS
 cellular_componentGO:0070419 nonhomologous end joining complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding TAS
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IDA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042162 telomeric DNA binding TAS
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity IMP


Pathways (from Reactome)
Pathway description
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000152422 XRCC4 / Q13426 / X-ray repair cross complementing 4  / reaction / complex
 ENSG00000253729 PRKDC / P78527 / protein kinase, DNA-activated, catalytic polypeptide  / reaction / complex
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction / complex
 ENSG00000174405 LIG4 / P49917 / DNA ligase 4  / reaction / complex
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / reaction / complex
 ENSG00000187736 NHEJ1 / Q9H9Q4 / non-homologous end joining factor 1  / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000166169 POLL / Q9UGP5 / DNA polymerase lambda  / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / reaction
 ENSG00000157212 PAXIP1 / Q6ZW49 / PAX interacting protein 1  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / reaction
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / reaction
 ENSG00000080345 RIF1 / Q5UIP0 / replication timing regulatory factor 1  / reaction
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction / complex
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / reaction
 ENSG00000122678 POLM / Q9NP87 / DNA polymerase mu  / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr