ENSG00000122678


Homo sapiens

Features
Gene ID: ENSG00000122678
  
Biological name :POLM
  
Synonyms : DNA polymerase mu / POLM / Q9NP87
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p13
Gene start: 44072247
Gene end: 44082540
  
Corresponding Affymetrix probe sets: 222238_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399244
Ensembl peptide - ENSP00000397135
Ensembl peptide - ENSP00000406750
Ensembl peptide - ENSP00000414025
Ensembl peptide - ENSP00000242248
Ensembl peptide - ENSP00000335141
Ensembl peptide - ENSP00000379174
Ensembl peptide - ENSP00000388230
Ensembl peptide - ENSP00000390899
Ensembl peptide - ENSP00000395043
Ensembl peptide - ENSP00000396571
NCBI entrez gene - 27434     See in Manteia.
OMIM - 606344
RefSeq - XM_017012005
RefSeq - XM_011515275
RefSeq - XM_011515278
RefSeq - XM_011515279
RefSeq - XM_011515286
RefSeq - XM_011515287
RefSeq - XM_017011998
RefSeq - XM_017011999
RefSeq - XM_017012000
RefSeq - XM_017012001
RefSeq - XM_017012002
RefSeq - XM_017012003
RefSeq - XM_017012004
RefSeq - NM_001284330
RefSeq - NM_001284331
RefSeq - NM_013284
RefSeq - XM_005249711
RefSeq - XM_006715692
RefSeq - XM_006715696
RefSeq Peptide - NP_001271260
RefSeq Peptide - NP_037416
RefSeq Peptide - NP_001271259
swissprot - F8WEJ1
swissprot - H7C2M2
swissprot - Q9H980
swissprot - Q9NP87
swissprot - C9J222
swissprot - C9JF34
swissprot - Q6PIY2
swissprot - F8WB78
swissprot - F8WDE4
Ensembl - ENSG00000122678
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polmENSDARG00000103470Danio rerio
 PolmENSMUSG00000020474Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNTT / P04053 / DNA nucleotidylexotransferaseENSG0000010744727
POLL / Q9UGP5 / DNA polymerase lambdaENSG0000016616918
POLB / P06746 / DNA polymerase betaENSG000000705019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR001726  DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
 IPR002054  DNA-directed DNA polymerase X
 IPR010996  DNA polymerase beta-like, N-terminal domain
 IPR018944  DNA polymerase lambda, fingers domain
 IPR019843  DNA polymerase family X, binding site
 IPR022312  DNA polymerase family X
 IPR027249  DNA-directed DNA/RNA polymerase mu
 IPR027421  DNA polymerase lambda lyase domain superfamily
 IPR028207  DNA polymerase beta, palm domain
 IPR029398  DNA polymerase beta, thumb domain
 IPR036420  BRCT domain superfamily
 IPR037160  DNA polymerase, thumb domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0034061 DNA polymerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000152422 XRCC4 / Q13426 / X-ray repair cross complementing 4  / reaction
 ENSG00000253729 PRKDC / P78527 / protein kinase, DNA-activated, catalytic polypeptide  / reaction
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction
 ENSG00000174405 LIG4 / P49917 / DNA ligase 4  / reaction
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / reaction
 ENSG00000187736 NHEJ1 / Q9H9Q4 / non-homologous end joining factor 1  / reaction
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction






 

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