ENSG00000070501


Homo sapiens

Features
Gene ID: ENSG00000070501
  
Biological name :POLB
  
Synonyms : DNA polymerase beta / P06746 / POLB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p11.21
Gene start: 42338454
Gene end: 42371808
  
Corresponding Affymetrix probe sets: 203616_at (Human Genome U133 Plus 2.0 Array)   234907_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428578
Ensembl peptide - ENSP00000429436
Ensembl peptide - ENSP00000432084
Ensembl peptide - ENSP00000430831
Ensembl peptide - ENSP00000430784
Ensembl peptide - ENSP00000430610
Ensembl peptide - ENSP00000430478
Ensembl peptide - ENSP00000429597
Ensembl peptide - ENSP00000265421
Ensembl peptide - ENSP00000427799
Ensembl peptide - ENSP00000428144
NCBI entrez gene - 5423     See in Manteia.
OMIM - 174760
RefSeq - NM_002690
RefSeq - XM_017013584
RefSeq - XM_017013583
RefSeq - XM_006716353
RefSeq - XM_005273540
RefSeq - XM_005273539
RefSeq - XM_005273538
RefSeq - XM_005273537
RefSeq - XM_005273536
RefSeq - XM_005273535
RefSeq Peptide - NP_002681
swissprot - E9PIC6
swissprot - P06746
swissprot - H0YBX1
swissprot - H0YBJ0
swissprot - H0YB29
swissprot - H0YAV8
swissprot - E5RG65
swissprot - E5RHZ4
swissprot - E5RIJ0
swissprot - E5RJ55
swissprot - E7EW18
Ensembl - ENSG00000070501
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polbENSDARG00000003749Danio rerio
 PolbENSMUSG00000031536Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
POLL / Q9UGP5 / DNA polymerase lambdaENSG0000016616934
DNTT / P04053 / DNA nucleotidylexotransferaseENSG0000010744725
POLM / Q9NP87 / DNA polymerase muENSG0000012267813


Protein motifs (from Interpro)
Interpro ID Name
 IPR002008  DNA polymerase family X, beta-like
 IPR002054  DNA-directed DNA polymerase X
 IPR003583  Helix-hairpin-helix DNA-binding motif, class 1
 IPR010996  DNA polymerase beta-like, N-terminal domain
 IPR018944  DNA polymerase lambda, fingers domain
 IPR019843  DNA polymerase family X, binding site
 IPR022312  DNA polymerase family X
 IPR027421  DNA polymerase lambda lyase domain superfamily
 IPR028207  DNA polymerase beta, palm domain
 IPR029398  DNA polymerase beta, thumb domain
 IPR037160  DNA polymerase, thumb domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IMP
 biological_processGO:0006286 base-excision repair, base-free sugar-phosphate removal TAS
 biological_processGO:0006287 base-excision repair, gap-filling IEA
 biological_processGO:0006288 base-excision repair, DNA ligation TAS
 biological_processGO:0006290 pyrimidine dimer repair IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007435 salivary gland morphogenesis IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0016445 somatic diversification of immunoglobulins IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048535 lymph node development IEA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0071707 immunoglobulin heavy chain V-D-J recombination IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0034061 DNA polymerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
PCNA-Dependent Long Patch Base Excision Repair
Ub-specific processing proteases
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / reaction / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction
 ENSG00000105486 LIG1 / P18858 / DNA ligase 1  / reaction / complex
 ENSG00000073050 XRCC1 / P18887 / X-ray repair cross complementing 1  / complex / reaction
 ENSG00000005156 LIG3 / P49916 / DNA ligase 3  / reaction / complex
 ENSG00000039650 PNKP / Q96T60 / polynucleotide kinase 3-phosphatase  / reaction / complex
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / reaction
 ENSG00000170242 USP47 / Q96K76 / ubiquitin specific peptidase 47  / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction
 ENSG00000168496 FEN1 / P39748 / flap structure-specific endonuclease 1  / complex / reaction
 ENSG00000140398 NEIL1 / Q96FI4 / nei like DNA glycosylase 1  / reaction / complex
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / reaction






 

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