ENSG00000140398


Homo sapiens

Features
Gene ID: ENSG00000140398
  
Biological name :NEIL1
  
Synonyms : NEIL1 / nei like DNA glycosylase 1 / Q96FI4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q24.2
Gene start: 75346955
Gene end: 75357114
  
Corresponding Affymetrix probe sets: 219396_s_at (Human Genome U133 Plus 2.0 Array)   241477_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457541
Ensembl peptide - ENSP00000457352
Ensembl peptide - ENSP00000457371
Ensembl peptide - ENSP00000347170
Ensembl peptide - ENSP00000454292
Ensembl peptide - ENSP00000454729
Ensembl peptide - ENSP00000455730
Ensembl peptide - ENSP00000455745
Ensembl peptide - ENSP00000455949
Ensembl peptide - ENSP00000456466
Ensembl peptide - ENSP00000456852
Ensembl peptide - ENSP00000456945
Ensembl peptide - ENSP00000457056
Ensembl peptide - ENSP00000457081
NCBI entrez gene - 79661     See in Manteia.
OMIM - 608844
RefSeq - XM_017022567
RefSeq - XM_006720677
RefSeq - XM_006720678
RefSeq - XM_006720679
RefSeq - XM_006720680
RefSeq - XM_006720681
RefSeq - XM_011522001
RefSeq - XM_011522002
RefSeq - XM_011522003
RefSeq - XM_011522004
RefSeq - XM_011522005
RefSeq - XM_011522006
RefSeq - XM_011522007
RefSeq - XM_011522008
RefSeq - XM_017022566
RefSeq - NM_001256552
RefSeq - NM_024608
RefSeq - XM_005254659
RefSeq Peptide - NP_001243481
RefSeq Peptide - NP_078884
swissprot - H3BQU8
swissprot - H3BRZ2
swissprot - H3BST2
swissprot - H3BSZ5
swissprot - H3BT75
swissprot - H3BN83
swissprot - H3BTX5
swissprot - H3BU98
swissprot - Q96FI4
swissprot - H3BM98
swissprot - H3BT94
swissprot - H3BQE8
Ensembl - ENSG00000140398
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neil1ENSDARG00000018061Danio rerio
 NEIL1ENSGALG00000001586Gallus gallus
 Neil1ENSMUSG00000032298Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010979  Ribosomal protein S13-like, H2TH
 IPR012319  Formamidopyrimidine-DNA glycosylase, catalytic domain
 IPR015371  Endonuclease VIII-like 1, DNA binding
 IPR015886  DNA glycosylase/AP lyase, H2TH DNA-binding
 IPR035937  MutM-like, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0032074 negative regulation of nuclease activity IDA
 biological_processGO:0045008 depyrimidination TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity TAS
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000073050 XRCC1 / P18887 / X-ray repair cross complementing 1  / complex / reaction
 ENSG00000005156 LIG3 / P49916 / DNA ligase 3  / complex / reaction
 ENSG00000114026 OGG1 / O15527 / 8-oxoguanine DNA glycosylase  / reaction
 ENSG00000039650 PNKP / Q96T60 / polynucleotide kinase 3-phosphatase  / complex / reaction
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / complex / reaction






 

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