ENSG00000114026


Homo sapiens

Features
Gene ID: ENSG00000114026
  
Biological name :OGG1
  
Synonyms : 8-oxoguanine DNA glycosylase / O15527 / OGG1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p25.3
Gene start: 9749944
Gene end: 9788219
  
Corresponding Affymetrix probe sets: 1558556_at (Human Genome U133 Plus 2.0 Array)   205301_s_at (Human Genome U133 Plus 2.0 Array)   205760_s_at (Human Genome U133 Plus 2.0 Array)   215272_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345520
Ensembl peptide - ENSP00000344899
Ensembl peptide - ENSP00000373337
Ensembl peptide - ENSP00000403598
Ensembl peptide - ENSP00000402713
Ensembl peptide - ENSP00000399810
Ensembl peptide - ENSP00000396034
Ensembl peptide - ENSP00000393726
Ensembl peptide - ENSP00000390337
Ensembl peptide - ENSP00000303132
Ensembl peptide - ENSP00000305527
Ensembl peptide - ENSP00000305584
Ensembl peptide - ENSP00000306561
Ensembl peptide - ENSP00000342851
NCBI entrez gene - 4968     See in Manteia.
OMIM - 601982
RefSeq - XM_017006499
RefSeq - NM_002542
RefSeq - NM_016819
RefSeq - NM_016820
RefSeq - NM_016821
RefSeq - NM_016826
RefSeq - NM_016827
RefSeq - NM_016828
RefSeq - NM_016829
RefSeq - XM_011533760
RefSeq - XM_017006493
RefSeq - XM_017006494
RefSeq - XM_017006495
RefSeq - XM_017006496
RefSeq - XM_017006497
RefSeq - XM_017006498
RefSeq Peptide - NP_058436
RefSeq Peptide - NP_058437
RefSeq Peptide - NP_058438
RefSeq Peptide - NP_002533
RefSeq Peptide - NP_058212
RefSeq Peptide - NP_058213
RefSeq Peptide - NP_058214
RefSeq Peptide - NP_058434
swissprot - E5KPN0
swissprot - E5KPM9
swissprot - E5KPM8
swissprot - E5KPM7
swissprot - E5KPM6
swissprot - F8WCZ9
swissprot - H7BXZ1
swissprot - H7BZM3
swissprot - H7C0A1
swissprot - O15527
swissprot - E5KPM5
swissprot - H7C1D7
swissprot - H7C1V7
swissprot - E5KPN1
Ensembl - ENSG00000114026
  
Related genetic diseases (OMIM): 144700 - Renal cell carcinoma, clear cell, somatic, 144700
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ogg1ENSDARG00000060002Danio rerio
 OGG1ENSGALG00000006651Gallus gallus
 Ogg1ENSMUSG00000030271Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003265  HhH-GPD domain
 IPR004577  8-oxoguanine DNA-glycosylase
 IPR011257  DNA glycosylase
 IPR012904  8-oxoguanine DNA glycosylase, N-terminal
 IPR023170  Helix-turn-helix, base-excision DNA repair, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair TAS
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IGI
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009314 response to radiation IDA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IDA
 biological_processGO:0033683 nucleotide-excision repair, DNA incision IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045007 depurination TAS
 biological_processGO:0045008 depyrimidination TAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:1901291 negative regulation of double-strand break repair via single-strand annealing IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity IBA
 molecular_functionGO:0032357 oxidized purine DNA binding IDA
 molecular_functionGO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Displacement of DNA glycosylase by APEX1
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0003745 Sporadic 
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 HP:0005584 Renal cell carcinoma "Renal cell carcinoma (also known as hypernephroma) is the most common form of kidney cancer arising from the proximal renal tubule. The tissue of origin for renal cell carcinoma is the proximal renal tubular epithelium. Renal cell carcinoma can be classified as 1) clear cell carcinoma, 2) papillary carcinoma, 3) chromophobe renal carcinoma, and 4) collecting duct carcinoma." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / reaction
 ENSG00000140398 NEIL1 / Q96FI4 / nei like DNA glycosylase 1  / reaction






 

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