ENSMUSG00000030271


Mus musculus

Features
Gene ID: ENSMUSG00000030271
  
Biological name :Ogg1
  
Synonyms : 8-oxoguanine DNA-glycosylase 1 / O08760 / Ogg1
  
Possible biological names infered from orthology : 8-oxoguanine DNA glycosylase / O15527
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 113326972
Gene end: 113335068
  
Corresponding Affymetrix probe sets: 10540639 (MoGene1.0st)   1430078_a_at (Mouse Genome 430 2.0 Array)   1448815_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144905
Ensembl peptide - ENSMUSP00000032406
Ensembl peptide - ENSMUSP00000144792
NCBI entrez gene - 18294     See in Manteia.
MGI - MGI:1097693
RefSeq - XM_006505722
RefSeq - NM_010957
RefSeq - XM_006505720
RefSeq - XM_006505721
RefSeq Peptide - NP_035087
swissprot - O08760
swissprot - Q3UIL3
swissprot - A0A0N4SV11
swissprot - A0A0N4SUR7
Ensembl - ENSMUSG00000030271
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ogg1ENSDARG00000060002Danio rerio
 OGG1ENSGALG00000006651Gallus gallus
 OGG1ENSG00000114026Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003265  HhH-GPD domain
 IPR004577  8-oxoguanine DNA-glycosylase
 IPR011257  DNA glycosylase
 IPR012904  8-oxoguanine DNA glycosylase, N-terminal
 IPR023170  Helix-turn-helix, base-excision DNA repair, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006284 base-excision repair IMP
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033683 nucleotide-excision repair, DNA incision ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:1901291 negative regulation of double-strand break repair via single-strand annealing ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000702 oxidized base lesion DNA N-glycosylase activity TAS
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity TAS
 molecular_functionGO:0032357 oxidized purine DNA binding IEA
 molecular_functionGO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IMP
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine
Cleavage of the damaged purine
Displacement of DNA glycosylase by APEX1
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: KitlSl-18R/Kitl+
Genetic Background: C3.Cg-KitlSl-18R

Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-18R/Kitl+
Genetic Background: C3.Cg-KitlSl-18R

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0010947 abnormal single-strand DNA break repair "anomaly in the process of repair of single strand breaks in DNA; repair of such breaks is mediated by the same enzyme systems as are used in base excision repair" [GO:0000012]
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Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032298 Neil1 / Q8K4Q6 / Endonuclease 8-like 1 / Q96FI4* / nei like DNA glycosylase 1*  / reaction
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction






 

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