ENSMUSG00000032298


Mus musculus

Features
Gene ID: ENSMUSG00000032298
  
Biological name :Neil1
  
Synonyms : Endonuclease 8-like 1 / Neil1 / Q8K4Q6
  
Possible biological names infered from orthology : nei like DNA glycosylase 1 / Q96FI4
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 57142800
Gene end: 57148305
  
Corresponding Affymetrix probe sets: 10593887 (MoGene1.0st)   1452871_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034842
Ensembl peptide - ENSMUSP00000139917
Ensembl peptide - ENSMUSP00000141048
NCBI entrez gene - 72774     See in Manteia.
MGI - MGI:1920024
RefSeq - XM_011242818
RefSeq - NM_028347
RefSeq - XM_006511486
RefSeq - XM_006511487
RefSeq - XM_006511485
RefSeq Peptide - NP_082623
swissprot - Q8K4Q6
Ensembl - ENSMUSG00000032298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neil1ENSDARG00000018061Danio rerio
 NEIL1ENSGALG00000001586Gallus gallus
 NEIL1ENSG00000140398Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010979  Ribosomal protein S13-like, H2TH
 IPR012319  Formamidopyrimidine-DNA glycosylase, catalytic domain
 IPR015371  Endonuclease VIII-like 1, DNA binding
 IPR015886  DNA glycosylase/AP lyase, H2TH DNA-binding
 IPR035937  MutM-like, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IDA
 biological_processGO:0006284 base-excision repair ISO
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress ISO
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0032074 negative regulation of nuclease activity ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds ISO
 molecular_functionGO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IEA
 molecular_functionGO:0016829 lyase activity IDA
 molecular_functionGO:0019104 DNA N-glycosylase activity IDA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

Allelic Composition: Neil1tm1Rsld/Neil1+
Genetic Background: either: B6.129S1-Neil1tm1Rsld or (involves: 129S1/Sv * C57BL/6)

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030271 Ogg1 / O08760 / 8-oxoguanine DNA-glycosylase 1 / O15527* / 8-oxoguanine DNA glycosylase*  / reaction
 ENSMUSG00000031536 Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*  / reaction / complex
 ENSMUSG00000051768 Xrcc1 / Q60596 / X-ray repair complementing defective repair in Chinese hamster cells 1 / P18887* / X-ray repair cross complementing 1*  / reaction / complex






 

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