ENSG00000005156


Homo sapiens

Features
Gene ID: ENSG00000005156
  
Biological name :LIG3
  
Synonyms : DNA ligase 3 / LIG3 / P49916
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 34980494
Gene end: 35009743
  
Corresponding Affymetrix probe sets: 1554597_at (Human Genome U133 Plus 2.0 Array)   1554599_x_at (Human Genome U133 Plus 2.0 Array)   1555169_at (Human Genome U133 Plus 2.0 Array)   204123_at (Human Genome U133 Plus 2.0 Array)   207348_s_at (Human Genome U133 Plus 2.0 Array)   229861_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468479
Ensembl peptide - ENSP00000467063
Ensembl peptide - ENSP00000467757
Ensembl peptide - ENSP00000262327
Ensembl peptide - ENSP00000367787
Ensembl peptide - ENSP00000465288
Ensembl peptide - ENSP00000466278
NCBI entrez gene - 3980     See in Manteia.
OMIM - 600940
RefSeq - XM_017024624
RefSeq - NM_002311
RefSeq - NM_013975
RefSeq - XM_005257970
RefSeq - XM_006721896
RefSeq Peptide - NP_002302
RefSeq Peptide - NP_039269
swissprot - K7ELY6
swissprot - K7ENR9
swissprot - K7EQB6
swissprot - P49916
swissprot - K7ERZ5
swissprot - K7EJR4
Ensembl - ENSG00000005156
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lig3ENSDARG00000052553Danio rerio
 LIG3ENSGALG00000002288Gallus gallus
 Lig3ENSMUSG00000020697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LIG1 / P18858 / DNA ligase 1ENSG0000010548619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR001357  BRCT domain
 IPR001510  Zinc finger, PARP-type
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR031916  DNA ligase 3, BRCT domain
 IPR036420  BRCT domain superfamily
 IPR036599  DNA ligase, ATP-dependent, N-terminal domain superfamily
 IPR036957  Zinc finger, PARP-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006266 DNA ligation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006288 base-excision repair, DNA ligation IDA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling TAS
 biological_processGO:0006302 double-strand break repair IDA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0090298 negative regulation of mitochondrial DNA replication IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity TAS
 molecular_functionGO:0003910 DNA ligase (ATP) activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
HDR through MMEJ (alt-NHEJ)
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / reaction
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction
 ENSG00000073050 XRCC1 / P18887 / X-ray repair cross complementing 1  / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / reaction / complex
 ENSG00000039650 PNKP / Q96T60 / polynucleotide kinase 3-phosphatase  / reaction / complex
 ENSG00000140398 NEIL1 / Q96FI4 / nei like DNA glycosylase 1  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr