ENSMUSG00000020697


Mus musculus

Features
Gene ID: ENSMUSG00000020697
  
Biological name :Lig3
  
Synonyms : Lig3 / ligase III, DNA, ATP-dependent
  
Possible biological names infered from orthology : DNA ligase 3 / P49916
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 82781108
Gene end: 82804274
  
Corresponding Affymetrix probe sets: 10379564 (MoGene1.0st)   1423419_at (Mouse Genome 430 2.0 Array)   1425865_a_at (Mouse Genome 430 2.0 Array)   1431715_a_at (Mouse Genome 430 2.0 Array)   1437198_at (Mouse Genome 430 2.0 Array)   1453986_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134300
Ensembl peptide - ENSMUSP00000133849
Ensembl peptide - ENSMUSP00000134101
Ensembl peptide - ENSMUSP00000021039
Ensembl peptide - ENSMUSP00000079317
Ensembl peptide - ENSMUSP00000090525
Ensembl peptide - ENSMUSP00000133348
Ensembl peptide - ENSMUSP00000133672
Ensembl peptide - ENSMUSP00000133805
NCBI entrez gene - 16882     See in Manteia.
MGI - MGI:109152
RefSeq - XM_006532353
RefSeq - NM_001291245
RefSeq - NM_001291246
RefSeq - NM_001291247
RefSeq - NM_010716
RefSeq - XM_006532347
RefSeq - XM_006532348
RefSeq - XM_006532350
RefSeq Peptide - NP_001278175
RefSeq Peptide - NP_001278176
RefSeq Peptide - NP_034846
RefSeq Peptide - NP_001278174
swissprot - G3UYI8
swissprot - Q3TJN5
swissprot - Q3UC82
swissprot - Q80ZH7
swissprot - B1AT03
swissprot - K4DI59
Ensembl - ENSMUSG00000020697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lig3ENSDARG00000052553Danio rerio
 LIG3ENSGALG00000002288Gallus gallus
 LIG3ENSG00000005156Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*ENSMUSG0000005639418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR001357  BRCT domain
 IPR001510  Zinc finger, PARP-type
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR031916  DNA ligase 3, BRCT domain
 IPR036420  BRCT domain superfamily
 IPR036599  DNA ligase, ATP-dependent, N-terminal domain superfamily
 IPR036957  Zinc finger, PARP-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006266 DNA ligation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006288 base-excision repair, DNA ligation IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0090298 negative regulation of mitochondrial DNA replication IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
HDR through MMEJ (alt-NHEJ)
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Tlr4tm1Aki/Tlr4lps-2J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
Show

Allelic Composition: Tlr4tm1Aki/Tlr4lps-2J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr4tm1Aki/Tlr4lps-2J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Tlr4tm1Aki/Tlr4lps-2J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Tlr4tm1Aki/Tlr4lps-2J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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