ENSMUSG00000056394


Mus musculus

Features
Gene ID: ENSMUSG00000056394
  
Biological name :Lig1
  
Synonyms : Lig1 / ligase I, DNA, ATP-dependent
  
Possible biological names infered from orthology : DNA ligase 1 / P18858
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 13277283
Gene end: 13311433
  
Corresponding Affymetrix probe sets: 10550102 (MoGene1.0st)   1416641_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096411
Ensembl peptide - ENSMUSP00000126525
Ensembl peptide - ENSMUSP00000138907
Ensembl peptide - ENSMUSP00000136972
Ensembl peptide - ENSMUSP00000114872
Ensembl peptide - ENSMUSP00000121102
NCBI entrez gene - 16881     See in Manteia.
MGI - MGI:101789
RefSeq - NM_001083188
RefSeq - NM_001199310
RefSeq - NM_010715
RefSeq Peptide - NP_001186239
RefSeq Peptide - NP_034845
RefSeq Peptide - NP_001076657
swissprot - V9GWZ4
swissprot - D3YUW4
swissprot - Q3U4X8
swissprot - E9PV36
Ensembl - ENSMUSG00000056394
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lig1ENSDARG00000060041Danio rerio
 LIG1ENSG00000105486Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lig3 / ligase III, DNA, ATP-dependent / P49916* / DNA ligase 3*ENSMUSG0000002069719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR036599  DNA ligase, ATP-dependent, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006266 DNA ligation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Processive synthesis on the C-strand of the telomere
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lig1tm1Dwm/Lig1tm1Dwm
Genetic Background: involves: 129P2/OlaHsd

 MP:0000215 absent erythrocytes "lack of mature red blood cells" [J:23061]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Lig1tm2Dwm/Lig1tm2Dwm
Genetic Background: involves: 129P2/OlaHsd

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig1tm1Dwm/Lig1tm1Dwm
Genetic Background: involves: 129P2/OlaHsd

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lig1tm1Dwm/Lig1tm1Dwm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lig1tm2Dwm/Lig1tm2Dwm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Lig1tm1Dwm/Lig1tm1Dwm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lig1tm2Dwm/Lig1tm2Dwm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lig1tm2Dwm/Lig1tm2Dwm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Lig1tm2Dwm/Lig1tm2Dwm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lig1tm1Dwm/Lig1tm1Dwm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: Lig1tm1Dwm/Lig1tm1Dwm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008737 abnormal spleen physiology "any anomaly in the function of the organ that filters blood and stores red corpuscles and platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Lig1tm1Dwm/Lig1tm1Dwm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Lig1tm2Dwm/Lig1tm2Dwm
Genetic Background: involves: 129P2/OlaHsd

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Lig1tm1Dwm/Lig1tm1Dwm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / reaction / complex
 ENSMUSG00000031536 Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / complex / reaction
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex






 

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