ENSDARG00000052553


Danio rerio

Features
Gene ID: ENSDARG00000052553
  
Biological name :lig3
  
Synonyms : lig3 / ligase III, DNA, ATP-dependent
  
Possible biological names infered from orthology : DNA ligase 3 / P49916
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 60847823
Gene end: 60873092
  
Corresponding Affymetrix probe sets: Dr.4675.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000068915
NCBI entrez gene - 563276     See in Manteia.
RefSeq - NM_001030174
RefSeq Peptide - NP_001025345
swissprot - F1QJL4
swissprot - A0A0R4ITF1
ZFIN ID - ZDB-GENE-030131-8453
Ensembl - ENSDARG00000052553
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIG3ENSGALG00000002288Gallus gallus
 LIG3ENSG00000005156Homo sapiens
 Lig3ENSMUSG00000020697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*ENSDARG0000006004118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR001357  BRCT domain
 IPR001510  Zinc finger, PARP-type
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR031916  DNA ligase 3, BRCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IBA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0097681 double-strand break repair via alternative nonhomologous end joining IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
HDR through MMEJ (alt-NHEJ)
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003749 polb / polymerase (DNA directed), beta / P06746* / Q8K409* / DNA polymerase beta*  / complex / reaction
 ENSDARG00000018061 neil1 / nei-like DNA glycosylase 1 / Q8K4Q6* / Q96FI4* / Endonuclease 8-like 1 *  / complex / reaction
 ENSDARG00000009494 xrcc1 / X-ray repair complementing defective repair in Chinese hamster cells 1 / P18887* / Q60596* / X-ray repair cross complementing 1*  / complex
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / reaction / complex
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / reaction / complex
 ENSDARG00000100455 pnkp / polynucleotide kinase 3-phosphatase / Q96T60*  / complex / reaction






 

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