ENSDARG00000003749


Danio rerio

Features
Gene ID: ENSDARG00000003749
  
Biological name :polb
  
Synonyms : polb / polymerase (DNA directed), beta
  
Possible biological names infered from orthology : DNA polymerase beta / P06746 / Q8K409
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 2456854
Gene end: 2469761
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000017489
Ensembl peptide - ENSDARP00000118132
NCBI entrez gene - 554204     See in Manteia.
RefSeq - NM_001003879
RefSeq Peptide - NP_001003879
swissprot - B0R195
swissprot - B0R194
ZFIN ID - ZDB-GENE-040830-1
Ensembl - ENSDARG00000003749
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 POLBENSG00000070501Homo sapiens
 PolbENSMUSG00000031536Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
poll / polymerase (DNA directed), lambda / Q9QXE2* / Q9UGP5* / DNA polymerase lambda*ENSDARG0000003961333
polm / polymerase (DNA directed), mu / Q9JIW4* / Q9NP87* / DNA polymerase mu*ENSDARG0000010347025
dntt / deoxynucleotidyltransferase, terminal / P04053* / DNA nucleotidylexotransferase*ENSDARG0000010479224


Protein motifs (from Interpro)
Interpro ID Name
 IPR002008  DNA polymerase family X, beta-like
 IPR002054  DNA-directed DNA polymerase X
 IPR003583  Helix-hairpin-helix DNA-binding motif, class 1
 IPR010996  DNA polymerase beta-like, N-terminal domain
 IPR018944  DNA polymerase lambda, fingers domain
 IPR019843  DNA polymerase family X, binding site
 IPR022312  DNA polymerase family X
 IPR028207  DNA polymerase beta, palm domain
 IPR029398  DNA polymerase beta, thumb domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0034061 DNA polymerase activity IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
PCNA-Dependent Long Patch Base Excision Repair
Ub-specific processing proteases
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000112 gut gut quality , abnormal
gut hypoplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
Show

 ZFA:0001114 head head decreased width , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000060041 lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*  / reaction / complex
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / reaction
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction
 ENSDARG00000009494 xrcc1 / X-ray repair complementing defective repair in Chinese hamster cells 1 / P18887* / Q60596* / X-ray repair cross complementing 1*  / complex / reaction
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSDARG00000052553 lig3 / ligase III, DNA, ATP-dependent / P49916* / DNA ligase 3*  / reaction / complex
 ENSDARG00000011404 fen1 / Q6TNU4 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / reaction
 ENSDARG00000018061 neil1 / nei-like DNA glycosylase 1 / Q8K4Q6* / Q96FI4* / Endonuclease 8-like 1 *  / complex / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction
 ENSDARG00000100455 pnkp / polynucleotide kinase 3-phosphatase / Q96T60*  / reaction / complex
 ENSDARG00000102645 usp47 / ubiquitin specific peptidase 47 / Q96K76*  / complex






 

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