ENSDARG00000019529


Danio rerio

Features
Gene ID: ENSDARG00000019529
  
Biological name :parp1
  
Synonyms : parp1 / poly (ADP-ribose) polymerase 1
  
Possible biological names infered from orthology : P09874 / poly (ADP-ribose) polymerase family, member 1
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 43648369
Gene end: 43689779
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000008364
Ensembl peptide - ENSDARP00000156256
NCBI entrez gene - 560788     See in Manteia.
RefSeq - NM_001044942
RefSeq Peptide - NP_001038407
swissprot - Q499A8
swissprot - Q5RHR0
ZFIN ID - ZDB-GENE-030131-3955
Ensembl - ENSDARG00000019529
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PARP1ENSGALG00000009228Gallus gallus
 PARP1ENSG00000143799Homo sapiens
 Parp1ENSMUSG00000026496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
parp2 / poly (ADP-ribose) polymerase 2 / O88554* / Q9UGN5*ENSDARG0000007920221
parp3 / poly (ADP-ribose) polymerase family, member 3 / Q9Y6F1*ENSDARG0000000396116


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR001510  Zinc finger, PARP-type
 IPR004102  Poly(ADP-ribose) polymerase, regulatory domain
 IPR008288  Poly [ADP-ribose] polymerase
 IPR008893  WGR domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR012982  PADR1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006273 lagging strand elongation IBA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003749 polb / polymerase (DNA directed), beta / P06746* / Q8K409* / DNA polymerase beta*  / complex / reaction
 ENSDARG00000060510 cul4b / cullin 4B / A2A432* / Q13620*  / reaction / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSDARG00000101510 cetn2 / centrin, EF-hand protein, 2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / reaction / complex
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000044622 polq / polymerase (DNA directed), theta / O75417* / Q8CGS6* / DNA polymerase theta*  / complex / reaction
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / complex
 ENSDARG00000021550 rad23b / RAD23 homolog B, nucleotide excision repair protein / P54727*  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSDARG00000041140 ddb2 / Q2YDS1 / damage-specific DNA binding protein 2 / Q92466* / Q99J79* / DNA damage-binding protein 2 *  / complex / reaction
 ENSDARG00000039754 xpc / xeroderma pigmentosum, complementation group C / P51612* / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / reaction / complex
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / reaction
 ENSDARG00000096578 cul4a / cullin 4A / Q13619* / Q3TCH7*  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000011404 fen1 / Q6TNU4 / flap structure-specific endonuclease 1 / P39748*  / reaction / complex
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / reaction / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000061114 parga / poly (ADP-ribose) glycohydrolase a / PARG* / Q86W56* / poly(ADP-ribose) glycohydrolase*  / reaction






 

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