ENSDARG00000096578


Danio rerio

Features
Gene ID: ENSDARG00000096578
  
Biological name :cul4a
  
Synonyms : cul4a / cullin 4A
  
Possible biological names infered from orthology : Q13619 / Q3TCH7
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 157793
Gene end: 167398
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131646
Ensembl peptide - ENSDARP00000126706
NCBI entrez gene - 394002     See in Manteia.
swissprot - Q7T2C1
swissprot - R4GDZ6
swissprot - A0A0H2UKI1
ZFIN ID - ZDB-GENE-040426-1357
Ensembl - ENSDARG00000096578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CUL4AENSGALG00000016830Gallus gallus
 CUL4AENSG00000139842Homo sapiens
 Cul4aENSMUSG00000031446Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cul4b / cullin 4B / A2A432* / Q13620*ENSDARG0000006051078
cul3a / cullin 3a / CUL3* / Q13618* / Q9JLV5* / cullin 3*ENSDARG0000003896738
cul3b / cullin 3b / CUL3* / Q13618* / Q9JLV5* / cullin 3*ENSDARG0000010010838
cul1b / cullin 1b / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSDARG0000000769130
cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSDARG0000001923930
cul5a / cullin 5a / CUL5* / Q93034* / cullin 5*ENSDARG0000006974226
cul5b / cullin 5b / CUL5* / Q93034* / cullin 5*ENSDARG0000000426026
cul2 / cullin 2 / Q13617* / Q9D4H8*ENSDARG0000001396525


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0035118 embryonic pectoral fin morphogenesis IMP
 biological_processGO:0071600 otic vesicle morphogenesis IMP
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle shape , abnormal
cardiac ventricle cell spatial pattern , abnormal
Show

 ZFA:0000029 hindbrain hindbrain edematous , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000085 apical ectodermal ridge pectoral fin bud apical ectodermal ridge pectoral fin bud physical object quality , abnormal
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 ZFA:0000114 heart heart shape , abnormal
heart morphology , abnormal
heart cell proliferation decreased process quality , abnormal
heart apoptotic process increased process quality , abnormal
Show

 ZFA:0000471 atrium atrium shape , abnormal
atrium cell spatial pattern , abnormal
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 ZFA:0001058 caudal fin caudal fin curled , abnormal
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 ZFA:0001161 pectoral fin pectoral fin absent , abnormal
pectoral fin truncated , abnormal
pectoral fin decreased length , abnormal
pectoral fin cell proliferation decreased process quality , abnormal
pectoral fin decreased size , abnormal
pectoral fin malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / reaction / complex
 ENSDARG00000007989 nedd8 / neural precursor cell expressed, developmentally down-regulated 8 / P29595* / Q15843*  / complex / reaction
 ENSDARG00000023002 dtl / Q5RHI5 / denticleless E3 ubiquitin protein ligase homolog (Drosophila) / Q9NZJ0* / Q3TLR7* / Denticleless protein homolog * / denticleless E3 ubiquitin protein ligase homolog*  / complex
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction / complex
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction / complex
 ENSDARG00000041140 ddb2 / Q2YDS1 / damage-specific DNA binding protein 2 / Q92466* / Q99J79* / DNA damage-binding protein 2 *  / complex
 ENSDARG00000057624 cops5 / Q6PC30 / COP9 signalosome subunit 5 / O35864* / Q92905* / COP9 signalosome complex subunit 5 *  / reaction
 ENSDARG00000031203 commd1 / copper metabolism (Murr1) domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 * / copper metabolism domain containing 1*  / reaction / complex
 ENSDARG00000075612 ercc6 / excision repair cross-complementation group 6 / P0DP91* / Q03468* / Q8N328* / ERCC excision repair 6, chromatin remodeling factor*  / complex / reaction
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSDARG00000101510 cetn2 / centrin, EF-hand protein, 2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / complex / reaction
 ENSDARG00000021550 rad23b / RAD23 homolog B, nucleotide excision repair protein / P54727*  / complex / reaction
 ENSDARG00000039754 xpc / xeroderma pigmentosum, complementation group C / P51612* / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / complex / reaction
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex






 

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