ENSDARG00000007691


Danio rerio

Features
Gene ID: ENSDARG00000007691
  
Biological name :cul1b
  
Synonyms : cul1b / cullin 1b
  
Possible biological names infered from orthology : CUL1 / cullin 1 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616 / Q9WTX6
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 17364745
Gene end: 17400472
  
Corresponding Affymetrix probe sets: Dr.7761.1.A1_at (Zebrafish Array)   NM_213495_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000118996
Ensembl peptide - ENSDARP00000110769
Ensembl peptide - ENSDARP00000002286
NCBI entrez gene - 406816     See in Manteia.
RefSeq - NM_213495
RefSeq - XM_021470126
RefSeq Peptide - NP_998660
swissprot - F1QV12
swissprot - F1Q7M5
swissprot - Q502R5
ZFIN ID - ZDB-GENE-040426-2887
Ensembl - ENSDARG00000007691
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CUL1ENSGALG00000036941Gallus gallus
 CUL1ENSG00000055130Homo sapiens
 Cul1ENSMUSG00000029686Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSDARG0000001923995
cul2 / cullin 2 / Q13617* / Q9D4H8*ENSDARG0000001396537
cul3a / cullin 3a / CUL3* / Q13618* / Q9JLV5* / cullin 3*ENSDARG0000003896730
cul4b / cullin 4B / A2A432* / Q13620*ENSDARG0000006051030
cul3b / cullin 3b / CUL3* / Q13618* / Q9JLV5* / cullin 3*ENSDARG0000010010830
cul5b / cullin 5b / CUL5* / Q93034* / cullin 5*ENSDARG0000000426029
cul5a / cullin 5a / CUL5* / Q93034* / cullin 5*ENSDARG0000006974229
cul4a / cullin 4A / Q13619* / Q3TCH7*ENSDARG0000009657825


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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