ENSGALG00000036941


Gallus gallus

Features
Gene ID: ENSGALG00000036941
  
Biological name :CUL1
  
Synonyms : CUL1 / cullin 1
  
Possible biological names infered from orthology : Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616 / Q9WTX6
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 54413610
Gene end: 54449714
  
Corresponding Affymetrix probe sets: Gga.16583.1.S1_at (Chicken Array)   GgaAffx.23892.1.S1_s_at (Chicken Array)   GgaAffx.23892.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046909
NCBI entrez gene - 420783     See in Manteia.
RefSeq - XM_015275907
RefSeq - XM_418878
swissprot - A0A1D5P2L3
Ensembl - ENSGALG00000036941
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul1aENSDARG00000019239Danio rerio
 cul1bENSDARG00000007691Danio rerio
 CUL1ENSG00000055130Homo sapiens
 Cul1ENSMUSG00000029686Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUL2 / cullin-2 / Q13617* / Q9D4H8*ENSGALG0000000709537
CUL3 / cullin 3 / Q13618* / Q9JLV5*ENSGALG0000000510830
CUL4B / cullin 4B / A2A432* / Q13620*ENSGALG0000000855930
CUL4A / cullin 4A / Q13619* / Q3TCH7*ENSGALG0000001683030
CUL5 / cullin 5 / Q93034*ENSGALG0000001716529


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002085 FZR1 / fizzy-related protein homolog / Q9R1K5* / Q9UM11* / fizzy and cell division cycle 20 related 1*  / complex / reaction
 ENSGALG00000002229 FBXW11 / F-box and WD repeat domain containing 11 / Q5SRY7* / Q9UKB1* / F-box/WD repeat-containing protein 11 *  / complex
 ENSGALG00000004611 FBXL18 / F-box and leucine rich repeat protein 18 / Q96ME1*  / complex
 ENSGALG00000008931 COMMD1 / copper metabolism domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 *  / complex
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000009971 CDC20 / cell division cycle 20 / Q12834* / Q9JJ66* / Cell division cycle *  / complex / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSGALG00000028664 CKS1B / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000002267 DCUN1D3 / defective in cullin neddylation 1 domain containing 3 / Q8IWE4* / Q8K0V2* / DCN1-like protein 3 *  / reaction / complex
 ENSGALG00000000249 GH / P08998 / Somatotropin / GH2* / GH1* / CSH1* / CSH2* / CSHL1* / Q14406* / P0DML3* / P0DML2* / P01241* / P01242* / P06880* / growth hormone 1* / growth hormone 2* / chorionic somatomamm...  / reaction / complex
 ENSGALG00000040794 CCNE2 / cyclin E2 / O96020* / Q9Z238* / G1/S-specific cyclin-E2 *  / reaction / complex
 ENSGALG00000012671 prl / P14676 / Prolactin / P04095* / P04768* / P04769* / P06879* / P09586* / Prl2a1* / Prl2b1* / Prl2c1* / Prl2c2* / Prl2c3* / Prl2c5* / Prl3a1* / Prl3b1* / Prl3c1* / Prl3d1* / Prl3d2* / P...  / complex / reaction
 ENSGALG00000022980 CDKN1B / cyclin dependent kinase inhibitor 1B / P46414* / P46527*  / reaction / complex
 ENSGALG00000029691 NFKBIB / NFKB inhibitor beta / Q15653* / Q60778* / NF-kappa-B inhibitor beta *  / complex / reaction
 ENSGALG00000007845 REL / REL proto-oncogene, NF-kB subunit / Q04864* / reticuloendotheliosis oncogene*  / reaction / complex
 ENSGALG00000016931 BORA / Q6PGQ7* / Q8BS90* / Protein aurora borealis * / bora, aurora kinase A activator*  / complex / reaction
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSGALG00000015666 TNIP2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / reaction / complex
 ENSGALG00000007356 MAP3K8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / reaction / complex
 ENSGALG00000044525 NFKBIE / NFKB inhibitor epsilon / O00221* / O54910* / NF-kappa-B inhibitor epsilon *  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000007768 AURKA / aurora kinase A / O14965* / P97477*  / complex / reaction
 ENSGALG00000040276 RUNX2 / runt related transcription factor 2 / Q08775* / Q13950*  / reaction / complex






 

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