ENSGALG00000002229


Gallus gallus

Features
Gene ID: ENSGALG00000002229
  
Biological name :FBXW11
  
Synonyms : F-box and WD repeat domain containing 11 / FBXW11
  
Possible biological names infered from orthology : F-box/WD repeat-containing protein 11 / Q5SRY7 / Q9UKB1
  
Species: Gallus gallus
  
Chr. number: 13
Strand: 1
Band:
Gene start: 2822078
Gene end: 2888100
  
Corresponding Affymetrix probe sets: GgaAffx.13178.1.S1_at (Chicken Array)   GgaAffx.13178.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045042
Ensembl peptide - ENSGALP00000045390
Ensembl peptide - ENSGALP00000003484
NCBI entrez gene - 416181     See in Manteia.
RefSeq - XM_015293598
RefSeq - XM_015293594
RefSeq - XM_015293595
RefSeq - XM_015293596
RefSeq - XM_015293597
RefSeq - NM_001039262
RefSeq - XM_015293592
RefSeq - XM_015293593
RefSeq Peptide - NP_001034351
swissprot - A0A1D5NYD3
swissprot - A0A1D5NXE7
swissprot - Q5ZHQ9
Ensembl - ENSGALG00000002229
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw11aENSDARG00000104806Danio rerio
 fbxw11bENSDARG00000017230Danio rerio
 FBXW11ENSG00000072803Homo sapiens
 Fbxw11ENSMUSG00000020271Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BTRC / beta-transducin repeat containing E3 ubiquitin protein ligase / Q3ULA2* / Q9Y297* / F-box/WD repeat-containing protein 1A *ENSGALG0000000782086
FBXW7 / F-box and WD repeat domain containing 7 / Q8VBV4* / Q969H0* / F-box/WD repeat-containing protein 7 *ENSGALG0000001010327
ENSGALG0000001733626
TRAF7 / TNF receptor associated factor 7 / Q6Q0C0*ENSGALG0000000576720
ZNF106 / zinc finger protein 106 / Q9H2Y7* / Zfp106*ENSGALG0000000908119
CDRT1* / Q5XX13* / FBXW10* / O95170* / Q5SUS0* / CMT1A duplicated region transcript 1* / F-box/WD repeat-containing protein 10 * / F-box and WD repeat domain containing 10*ENSGALG0000004456718
FBXW2 / F-box and WD repeat domain containing 2 / Q9UKT8*ENSGALG0000000086416
WDR86 / WD repeat domain 86 / Q86TI4*ENSGALG0000001969014


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR021977  D domain of beta-TrCP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0042753 positive regulation of circadian rhythm IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000029691 NFKBIB / NFKB inhibitor beta / Q15653* / Q60778* / NF-kappa-B inhibitor beta *  / reaction / complex
 ENSGALG00000044525 NFKBIE / NFKB inhibitor epsilon / O00221* / O54910* / NF-kappa-B inhibitor epsilon *  / reaction / complex
 ENSGALG00000015666 TNIP2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / reaction / complex
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex
 ENSGALG00000016931 BORA / Q6PGQ7* / Q8BS90* / Protein aurora borealis * / bora, aurora kinase A activator*  / complex / reaction
 ENSGALG00000007356 MAP3K8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / reaction / complex
 ENSGALG00000007845 REL / REL proto-oncogene, NF-kB subunit / Q04864* / reticuloendotheliosis oncogene*  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction






 

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