ENSGALG00000007356


Gallus gallus

Features
Gene ID: ENSGALG00000007356
  
Biological name :MAP3K8
  
Synonyms : MAP3K8 / mitogen-activated protein kinase kinase kinase 8
  
Possible biological names infered from orthology : P41279 / Q07174
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 15017676
Gene end: 15034648
  
Corresponding Affymetrix probe sets: Gga.8861.1.S1_at (Chicken Array)   GgaAffx.4586.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011883
Ensembl peptide - ENSGALP00000057110
Ensembl peptide - ENSGALP00000053924
NCBI entrez gene - 420479     See in Manteia.
RefSeq - XM_015282086
RefSeq - XM_015282087
RefSeq - XM_015282088
RefSeq - XM_418581
swissprot - E1C848
swissprot - A0A1D5PVY1
Ensembl - ENSGALG00000007356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k8ENSDARG00000061710Danio rerio
 MAP3K8ENSG00000107968Homo sapiens
 Map3k8ENSMUSG00000024235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPKKK3LENSGALG0000000588423
MAP3K3 / mitogen-activated protein kinase kinase kinase 3 / Q61084* / Q99759*ENSGALG0000000052523
MAP3K14 / mitogen-activated protein kinase kinase kinase 14 / Q99558* / Q9WUL6*ENSGALG0000000068520
MAP3K1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*ENSGALG0000001471819
MAP3K19 / mitogen-activated protein kinase kinase kinase 19 / E9Q3S4* / Q56UN5*ENSGALG0000002845718
MAP3K2* / Q9Y2U5* / mitogen-activated protein kinase kinase kinase 2*ENSGALG0000001150210


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002229 FBXW11 / F-box and WD repeat domain containing 11 / Q5SRY7* / Q9UKB1* / F-box/WD repeat-containing protein 11 *  / reaction / complex
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000015666 TNIP2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / reaction / complex
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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