ENSG00000107968


Homo sapiens

Features
Gene ID: ENSG00000107968
  
Biological name :MAP3K8
  
Synonyms : MAP3K8 / mitogen-activated protein kinase kinase kinase 8 / P41279
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p11.23
Gene start: 30433937
Gene end: 30461833
  
Corresponding Affymetrix probe sets: 205027_s_at (Human Genome U133 Plus 2.0 Array)   235421_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443610
Ensembl peptide - ENSP00000263056
Ensembl peptide - ENSP00000364470
Ensembl peptide - ENSP00000391275
Ensembl peptide - ENSP00000409653
Ensembl peptide - ENSP00000364471
NCBI entrez gene - 1326     See in Manteia.
OMIM - 191195
RefSeq - XM_017015714
RefSeq - NM_001244134
RefSeq - NM_001320961
RefSeq - NM_005204
RefSeq - XM_017015707
RefSeq - XM_017015708
RefSeq - XM_017015709
RefSeq - XM_017015710
RefSeq - XM_017015711
RefSeq - XM_017015712
RefSeq - XM_017015713
RefSeq Peptide - NP_005195
RefSeq Peptide - NP_001307890
RefSeq Peptide - NP_001231063
swissprot - Q5T857
swissprot - Q5T853
swissprot - P41279
swissprot - Q5T854
Ensembl - ENSG00000107968
  
Related genetic diseases (OMIM): 211980 - Lung cancer, somatic, 211980
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k8ENSDARG00000061710Danio rerio
 MAP3K8ENSGALG00000007356Gallus gallus
 Map3k8ENSMUSG00000024235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14ENSG0000000606224
MAP3K3 / Q99759 / mitogen-activated protein kinase kinase kinase 3ENSG0000019890923
Q56UN5 / MAP3K19 / mitogen-activated protein kinase kinase kinase 19ENSG0000017660123
MAP3K2 / Q9Y2U5 / mitogen-activated protein kinase kinase kinase 2ENSG0000016996722
MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1ENSG0000009501520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017424  Mitogen-activated protein (MAP) kinase kinase kinase 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0051403 stress-activated MAPK cascade TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004709 MAP kinase kinase kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0006519 Alveolar cell carcinoma 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex
 ENSG00000169032 MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1  / reaction
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / reaction / complex
 ENSG00000065559 MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4  / reaction
 ENSG00000168884 TNIP2 / Q8NFZ5 / TNFAIP3 interacting protein 2  / reaction / complex
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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