ENSG00000169967


Homo sapiens

Features
Gene ID: ENSG00000169967
  
Biological name :MAP3K2
  
Synonyms : MAP3K2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q14.3
Gene start: 127298730
Gene end: 127388465
  
Corresponding Affymetrix probe sets: 1565130_at (Human Genome U133 Plus 2.0 Array)   1565131_x_at (Human Genome U133 Plus 2.0 Array)   221695_s_at (Human Genome U133 Plus 2.0 Array)   226441_at (Human Genome U133 Plus 2.0 Array)   226979_at (Human Genome U133 Plus 2.0 Array)   227073_at (Human Genome U133 Plus 2.0 Array)   235011_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000343463
Ensembl peptide - ENSP00000387246
Ensembl peptide - ENSP00000386313
NCBI entrez gene - 10746     See in Manteia.
OMIM - 609487
RefSeq - NM_006609
RefSeq Peptide - NP_006600
swissprot - A0A024RAH0
swissprot - F8W6K3
swissprot - Q9Y2U5
Ensembl - ENSG00000169967
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k2ENSDARG00000062884Danio rerio
 ENSGALG00000011502Gallus gallus
 Map3k2ENSMUSG00000024383Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP3K3 / Q99759 / mitogen-activated protein kinase kinase kinase 3ENSG0000019890967
Q56UN5 / MAP3K19 / mitogen-activated protein kinase kinase kinase 19ENSG0000017660134
MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1ENSG0000009501528
Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14ENSG0000000606222
MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8ENSG0000010796817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR034879  Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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