ENSMUSG00000024383


Mus musculus

Features
Gene ID: ENSMUSG00000024383
  
Biological name :Map3k2
  
Synonyms : Map3k2 / mitogen-activated protein kinase kinase kinase 2
  
Possible biological names infered from orthology : Q9Y2U5
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B1
Gene start: 32163089
Gene end: 32236751
  
Corresponding Affymetrix probe sets: 10454546 (MoGene1.0st)   1422250_at (Mouse Genome 430 2.0 Array)   1438719_at (Mouse Genome 430 2.0 Array)   1455597_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094326
NCBI entrez gene - 26405     See in Manteia.
MGI - MGI:1346873
RefSeq - NM_011946
RefSeq Peptide - NP_036076
swissprot - G5E8L8
Ensembl - ENSMUSG00000024383
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k2ENSDARG00000062884Danio rerio
 ENSGALG00000011502Gallus gallus
 MAP3K2ENSG00000169967Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k3 / Q61084 / Mitogen-activated protein kinase kinase kinase 3 / Q99759*ENSMUSG0000002070067
E9Q3S4 / Map3k19 / Mitogen-activated protein kinase kinase kinase 19 / Q56UN5*ENSMUSG0000005159032
Map3k1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*ENSMUSG0000002175428
Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*ENSMUSG0000002094121
Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*ENSMUSG0000002423517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR034879  Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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