ENSMUSG00000020700


Mus musculus

Features
Gene ID: ENSMUSG00000020700
  
Biological name :Map3k3
  
Synonyms : Map3k3 / Mitogen-activated protein kinase kinase kinase 3 / Q61084
  
Possible biological names infered from orthology : Q99759
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 106084613
Gene end: 106155446
  
Corresponding Affymetrix probe sets: 10382028 (MoGene1.0st)   1426686_s_at (Mouse Genome 430 2.0 Array)   1426687_at (Mouse Genome 430 2.0 Array)   1436522_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002044
NCBI entrez gene - 26406     See in Manteia.
MGI - MGI:1346874
RefSeq - NM_011947
RefSeq - XM_011249037
RefSeq Peptide - NP_036077
swissprot - Q61084
Ensembl - ENSMUSG00000020700
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k3ENSDARG00000060348Danio rerio
 MAP3K3ENSGALG00000000525Gallus gallus
 MAP3K3ENSG00000198909Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5*ENSMUSG0000002438366
E9Q3S4 / Map3k19 / Mitogen-activated protein kinase kinase kinase 19 / Q56UN5*ENSMUSG0000005159031
Map3k1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*ENSMUSG0000002175429
Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*ENSMUSG0000002094120
Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*ENSMUSG0000002423517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR034879  Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IDA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rev3ltm1Esp/Rev3ltm1Esp
Genetic Background: involves: C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rev3ltm1Esp/Rev3ltm1Esp
Genetic Background: involves: C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rev3ltm1Esp/Rev3ltm1Esp
Genetic Background: involves: C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rev3ltm1Esp/Rev3ltm1Esp
Genetic Background: involves: C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

Allelic Composition: Map3k3tm1Kuro/Map3k3tm1Kuro,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

Allelic Composition: Map3k3tm1Kuro/Map3k3tm1Kuro,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k3tm1Kuro/Map3k3tm1Kuro,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Map3k3tm1Kuro/Map3k3tm1Kuro,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Map3k3tm1Kuro/Map3k3tm1Kuro,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000015837 Q64337 / Sqstm1 / Sequestosome-1 / Q13501*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr