Manteia - Molecule gene

ENSMUSG00000021754

Mus musculus

Features

Gene ID:	ENSMUSG00000021754

Biological name :	Map3k1

Synonyms :	Map3k1 / mitogen-activated protein kinase kinase kinase 1

Possible biological names infered from orthology :	Q13233

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	D2.2
Gene start:	111746428
Gene end:	111808993

Corresponding Affymetrix probe sets:	10412100 (MoGene1.0st) 1424850_at (Mouse Genome 430 2.0 Array) 1443540_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000117863 Ensembl peptide - ENSMUSP00000104890 NCBI entrez gene - 26401 See in Manteia. MGI - MGI:1346872 RefSeq - NM_011945 RefSeq - XM_017315516 RefSeq - XM_017315517 RefSeq Peptide - NP_036075 swissprot - F8VQ72 swissprot - D3YVX9 Ensembl - ENSMUSG00000021754

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
map3k1	ENSDARG00000098405	Danio rerio
MAP3K1	ENSGALG00000014718	Gallus gallus
MAP3K1	ENSG00000095015	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
E9Q3S4 / Map3k19 / Mitogen-activated protein kinase kinase kinase 19 / Q56UN5*	ENSMUSG00000051590	14
Map3k2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5*	ENSMUSG00000024383	12
Map3k3 / Q61084 / Mitogen-activated protein kinase kinase kinase 3 / Q99759*	ENSMUSG00000020700	12
Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*	ENSMUSG00000020941	9
Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*	ENSMUSG00000024235	6

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR001841	Zinc finger, RING-type
IPR007527	Zinc finger, SWIM-type
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR016024	Armadillo-type fold
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0071260	cellular response to mechanical stimulus	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0019901	protein kinase binding	IEA

Pathways (from Reactome)

Pathway description

MyD88:Mal cascade initiated on plasma membrane

FCERI mediated MAPK activation

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

MyD88 cascade initiated on plasma membrane

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000043	organ of Corti degeneration	"a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Map3k1^tm1Yxia/Map3k1^tm1Yxia Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001273	decreased metastatic potential		Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0001302	eyelids open at birth	"widely open eyes instead of closed at perinatal stage" [J:51966]	Show Allelic Composition: Sp4^tm1Krc/Sp4^tm1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv Allelic Composition: Map3k1^Ga/Map3k1^Ga Genetic Background: involves: BALB/cGa
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tcf7l2^{tm3.1(cre/ERT2)Mrc}/Tcf7l2⁺,Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sp4^tm1Krc/Sp4^tm1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss
MP:0001485	abnormal pinna reflex	"failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0001853	heart inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0002655	abnormal keratinocyte morphology	"structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sp4^tm1Krc/Sp4^tm1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss
MP:0002750	exophthalmos	"protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0003153	early eyelid opening	"early average time for the first postnatal eye opening" [J:92240, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0003222	increased cardiomyocyte apoptosis	"increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0003448	altered tumor morphology	"changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0003727	abnormal retinal layer morphology	"malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0004396	decreased cochlear inner hair cell number	"decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k1^tm1Yxia/Map3k1^tm1Yxia Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004401	increased cochlear outer hair cell number	"increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Map3k1^goya/Map3k1⁺ Genetic Background: involves: C3H * C57BL/6J Allelic Composition: Map3k1^tm1Yxia/Map3k1^tm1Yxia Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Map3k1^tm1Yxia/Map3k1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004404	cochlear outer hair cell degeneration	"degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Map3k1^tm1Yxia/Map3k1^tm1Yxia Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004485	increased response of heart to induced stress	"increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0004883	abnormal blood vessel healing	"anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0005103	abnormal retinal pigmentation	"anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005253	abnormal eye physiology	"anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0005595	abnormal vascular smooth muscle physiology	"anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0009263	abnormal eyelid fusion	"anomaly in the process by which the upper and lower eyelids are joined during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sp4^tm1Krc/Sp4^tm1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss
MP:0009651	abnormal eyelid development	"aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sp4^tm1Krc/Sp4^tm1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv Allelic Composition: Map3k1^Ga/Map3k1^Ga Genetic Background: involves: BALB/cGa
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0010088	decreased circulating fructosamine level	"decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010299	increased mammary gland tumor incidence	"greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0011707	impaired fibroblast cell migration	"failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]	Show Allelic Composition: Map3k1^tm1Glj/Map3k1^tm1Glj Genetic Background: involves: 129S/SvEv
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg},Tg(CAG-XBP1/Venus)#Miur/? Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Map3k1^tm1Yxia/Map3k1^tm1Yxia Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Map3k1^goya/Map3k1^tm1Yxia Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0013278	decreased fasted circulating glucose level	"reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013745	abnormal eyelid margin morphology	"any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium" [http://one.aao.org/bcscsnippetdetail.aspx?id=2b7328d7-5eb2-4df3-812a-031ff1c1f904, http://www.medilexicon.com/medicaldictionary.php?s=palpebral+margins, MGI:Anna]	Show Allelic Composition: Sp4^tm1Krc/Sp4^tm1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000027164	Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*	/ complex / reaction
ENSMUSG00000033352	Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*	/ reaction
ENSMUSG00000002948	Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr