ENSMUSG00000033352


Mus musculus

Features
Gene ID: ENSMUSG00000033352
  
Biological name :Map2k4
  
Synonyms : Dual specificity mitogen-activated protein kinase kinase 4 / Map2k4 / P47809
  
Possible biological names infered from orthology : mitogen-activated protein kinase kinase 4 / P45985
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 65688243
Gene end: 65788297
  
Corresponding Affymetrix probe sets: 10387014 (MoGene1.0st)   1426233_at (Mouse Genome 430 2.0 Array)   1451982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154113
Ensembl peptide - ENSMUSP00000137819
Ensembl peptide - ENSMUSP00000137955
Ensembl peptide - ENSMUSP00000041282
Ensembl peptide - ENSMUSP00000114219
Ensembl peptide - ENSMUSP00000137656
NCBI entrez gene - 26398     See in Manteia.
MGI - MGI:1346869
RefSeq - XM_017314561
RefSeq - NM_001316367
RefSeq - NM_001316368
RefSeq - NM_001316369
RefSeq - NM_009157
RefSeq - XM_006533370
RefSeq - XM_011249033
RefSeq Peptide - NP_001303298
RefSeq Peptide - NP_033183
RefSeq Peptide - NP_001303296
RefSeq Peptide - NP_001303297
swissprot - P47809
swissprot - B1ATL6
swissprot - Q543X6
swissprot - M0QWG5
swissprot - M0QWR0
swissprot - M0QW52
Ensembl - ENSMUSG00000033352
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k4aENSDARG00000063583Danio rerio
 map2k4bENSDARG00000077177Danio rerio
 MAP2K4ENSGALG00000032178Gallus gallus
 MAP2K4ENSG00000065559Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*ENSMUSG0000002062346
Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*ENSMUSG0000001893245
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000000294844
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000010906144
Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*ENSMUSG0000003502733
Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*ENSMUSG0000000493633
Map2k5 / Q9WVS7 / Dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / mitogen-activated protein kinase kinase 5*ENSMUSG0000005844432


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IPI
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0072709 cellular response to sorbitol IEA
 biological_processGO:2000672 negative regulation of motor neuron apoptotic process IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008545 JUN kinase kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Map2k4tm1Ctr/Map2k4tm1Ctr,Tg(ACTA1-cre)1Mll/?
Genetic Background: involves: C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

 MP:0012235 abnormal liver bud morphology "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000020366 Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*  / reaction
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction
 ENSMUSG00000021754 Map3k1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*  / reaction






 

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