ENSDARG00000063583


Danio rerio

Features
Gene ID: ENSDARG00000063583
  
Biological name :map2k4a
  
Synonyms : map2k4a / mitogen-activated protein kinase kinase 4a
  
Possible biological names infered from orthology : Dual specificity mitogen-activated protein kinase kinase 4 / MAP2K4 / mitogen-activated protein kinase kinase 4 / P45985 / P47809
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 10592597
Gene end: 10634532
  
Corresponding Affymetrix probe sets: Dr.10451.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000106153
Ensembl peptide - ENSDARP00000147340
Ensembl peptide - ENSDARP00000128981
Ensembl peptide - ENSDARP00000058833
Ensembl peptide - ENSDARP00000087469
NCBI entrez gene - 403052     See in Manteia.
swissprot - E7F090
swissprot - B1NA68
swissprot - F1RDF6
swissprot - Q9DGR7
swissprot - X1WFH7
ZFIN ID - ZDB-GENE-060512-98
Ensembl - ENSDARG00000063583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP2K4ENSGALG00000032178Gallus gallus
 MAP2K4ENSG00000065559Homo sapiens
 Map2k4ENSMUSG00000033352Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map2k4b / mitogen-activated protein kinase kinase 4b / P45985* / MAP2K4* / P47809* / mitogen-activated protein kinase kinase 4* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSDARG0000007717783
map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*ENSDARG0000009918446
map2k7 / mitogen-activated protein kinase kinase 7 / O14733* / Q8CE90* / Dual specificity mitogen-activated protein kinase kinase 7 *ENSDARG0000000827943
map2k1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *ENSDARG0000000782533
map2k2b / mitogen-activated protein kinase kinase 2b / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...ENSDARG0000006891832
map2k2a / mitogen-activated protein kinase kinase 2a / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...ENSDARG0000000660931
map2k5 / mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / Dual specificity mitogen-activated protein kinase kinase 5 *ENSDARG0000001185130


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade IMP
 biological_processGO:0007257 activation of JUN kinase activity IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0048263 determination of dorsal identity IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism wholly ventralized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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